PMID- 1984482
OWN - NLM
STAT- MEDLINE
DCOM- 19910125
LR  - 20220408
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 163
IP  - 1
DP  - 1991 Jan
TI  - Tumor necrosis factor and severe malaria.
PG  - 96-101
AB  - To investigate the relation of tumor necrosis factor-alpha (TNF alpha) to 
      Plasmodium falciparum infection, plasma TNF alpha concentrations were measured in 
      Zairian children with severe malaria, mild malaria, or other illnesses. The 
      initial geometric mean plasma concentration of TNF alpha among 61 children with 
      P. falciparum infection, (71 pg/ml) was higher than the level in 26 severely ill, 
      aparasitemic children (10 pg/ml; P less than .001). Among 29 parasitemic 
      children, initial geometric mean TNF alpha levels decreased from 77 to 5 pg/ml (P 
      less than .001) at day 7. TNF alpha levels increased with parasite density and 
      were associated with hyperparasitemia, severe anemia, hypoglycemia, and young age 
      but not with cerebral malaria or fatal outcome. However, TNF alpha levels were 
      elevated equally in children with cerebral malaria and with other signs of severe 
      malaria. With multiple linear regression, TNF alpha levels were elevated 
      independently in children with hyperparasitemia (P = .001) and severe anemia (P = 
      .04). In this study, high TNF alpha levels were associated with several 
      manifestations of severe malaria and were not specific to cerebral malaria.
FAU - Shaffer, N
AU  - Shaffer N
AD  - Malaria Branch, Centers for Disease Control, Atlanta, GA 30333.
FAU - Grau, G E
AU  - Grau GE
FAU - Hedberg, K
AU  - Hedberg K
FAU - Davachi, F
AU  - Davachi F
FAU - Lyamba, B
AU  - Lyamba B
FAU - Hightower, A W
AU  - Hightower AW
FAU - Breman, J G
AU  - Breman JG
FAU - Phuc, N D
AU  - Phuc ND
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Brain Diseases/complications/diagnosis/*immunology
MH  - Child
MH  - Child, Preschool
MH  - Humans
MH  - Infant
MH  - Malaria/complications/diagnosis/*immunology
MH  - Multivariate Analysis
MH  - Plasmodium falciparum/*isolation & purification
MH  - Prognosis
MH  - Regression Analysis
MH  - Sepsis/complications
MH  - Tumor Necrosis Factor-alpha/*analysis
EDAT- 1991/01/01 00:00
MHDA- 1991/01/01 00:01
CRDT- 1991/01/01 00:00
PHST- 1991/01/01 00:00 [pubmed]
PHST- 1991/01/01 00:01 [medline]
PHST- 1991/01/01 00:00 [entrez]
AID - 10.1093/infdis/163.1.96 [doi]
PST - ppublish
SO  - J Infect Dis. 1991 Jan;163(1):96-101. doi: 10.1093/infdis/163.1.96.