PMID- 19845100
OWN - NLM
STAT- MEDLINE
DCOM- 20091208
LR  - 20181201
IS  - 0301-150X (Print)
IS  - 0301-150X (Linking)
VI  - 49
IP  - 6-7
DP  - 2009 Sep-Oct
TI  - EMLA cream for carpal tunnel syndrome: how it compares with steroid injection.
PG  - 287-9
AB  - BACKGROUND: A standard treatment option for carpal tunnel syndrome (CTS) is local 
      injection of anesthetic-corticosteroid. This clinical trial was designed to 
      compare the safety and efficacy of daily application of the EMLA cream (lidocaine 
      2.5% plus prilocaine 2.5%) with that of a single injection of methyl prednisolone 
      acetate (Depo-Medrol) 40 mg. METHODS: In this randomized, parallel-group, 
      open-label, single-center, case-controlled, prospective study, 65 participants 
      (70 hands) aged 18-75 years with clinical & electrodiagnostic evidences of CTS 
      were randomized to receive either the EMLA cream (n = 30 patients, 35 hands, 
      group 1) or one injection of methylprednisolone acetate 40 mg at wrist (n = 35 
      patients, group 2). Outcome assessments included the visual analog scale and 
      clinical assessment. RESULTS: After 4 weeks of treatment, patients in both groups 
      reported significant changes (P < 0.001) in pain intensity. Both treatments were 
      well tolerated, with treatment-related adverse events (AEs) reported in 2 
      patients in group 1 (5.7%) and 10 patients in group 2 (28.5%) No systemic 
      treatment-related AEs were observed with the EMLA cream. CONCLUSION: EMLA cream 
      was effective in reducing pain associated with CTS and well tolerated and it may 
      offer patients with CTS an effective, noninvasive symptomatic treatment.
FAU - Moghtaderi, A R
AU  - Moghtaderi AR
AD  - Shiraz University of Medical Sciences, Shiraz, Iran. moghtaderia@yahoo.com
FAU - Jazayeri, S M
AU  - Jazayeri SM
FAU - Azizi, S
AU  - Azizi S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Belgium
TA  - Electromyogr Clin Neurophysiol
JT  - Electromyography and clinical neurophysiology
JID - 0327533
RN  - 0 (Anesthetics, Combined)
RN  - 0 (Lidocaine, Prilocaine Drug Combination)
RN  - 0 (Ointments)
RN  - 046O35D44R (Prilocaine)
RN  - 98PI200987 (Lidocaine)
RN  - 9PHQ9Y1OLM (Prednisolone)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Anesthetics, Combined/administration & dosage/*therapeutic use
MH  - Carpal Tunnel Syndrome/*drug therapy
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Injections
MH  - Lidocaine/administration & dosage/*therapeutic use
MH  - Lidocaine, Prilocaine Drug Combination
MH  - Male
MH  - Middle Aged
MH  - Ointments
MH  - Pain Measurement
MH  - Pilot Projects
MH  - Prednisolone/administration & dosage/*therapeutic use
MH  - Prilocaine/administration & dosage/*therapeutic use
MH  - Prospective Studies
MH  - Statistics, Nonparametric
MH  - Treatment Outcome
EDAT- 2009/10/23 06:00
MHDA- 2009/12/16 06:00
CRDT- 2009/10/23 06:00
PHST- 2009/10/23 06:00 [entrez]
PHST- 2009/10/23 06:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
PST - ppublish
SO  - Electromyogr Clin Neurophysiol. 2009 Sep-Oct;49(6-7):287-9.