PMID- 19845571
OWN - NLM
STAT- MEDLINE
DCOM- 20100820
LR  - 20220409
IS  - 1398-9995 (Electronic)
IS  - 0105-4538 (Linking)
VI  - 65
IP  - 5
DP  - 2010 May
TI  - Coagulation/fibrinolysis and inflammation markers are associated with disease 
      activity in patients with chronic urticaria.
PG  - 649-56
LID - 10.1111/j.1398-9995.2009.02222.x [doi]
AB  - BACKGROUND: The evaluation of disease severity and activity of chronic urticaria 
      (CU) is essential for the adequate treatment of patients. However, there is no 
      reliable biomarker for such evaluations. Recently, markers of blood coagulation 
      and fibrinolysis have been revealed to be elevated in severe cases of CU. In this 
      article, we studied the coagulation/fibrinolysis and inflammation markers and 
      their relationship to disease activity in patients with CU. METHODS: Plasma 
      fibrin degradation products (FDP), d-dimer and serum C-reactive protein (CRP) 
      were measured with the assessment of disease severity and skin reaction to 
      autologous serum in 82 patients with CU and 37 patients with acute urticaria, 
      idiopathic angioedema (AE) or inducible types of urticaria (IU). RESULTS: The 
      levels of FDP in patients with CU were significantly higher than those in 
      patients with IU, but no other differences in FDP, d-dimer and CRP were observed 
      among patients with different types of urticaria. These markers of patients with 
      CU were well correlated with each other and significantly associated with disease 
      severity of CU, but not with skin reactions to autologous serum. In 37 patients 
      with CU, levels of all these parameters reduced as their disease condition 
      improved, while they increased when the disease became aggravated. Regarding FDP, 
      this relationship was observed even if FDP concentrations were within normal 
      range throughout the study. CONCLUSIONS: The measurement of plasma FDP, d-dimer 
      and serum CRP may be useful for the assessment of disease activity of CU.
FAU - Takahagi, S
AU  - Takahagi S
AD  - Department of Dermatology, Hiroshima University, Japan.
FAU - Mihara, S
AU  - Mihara S
FAU - Iwamoto, K
AU  - Iwamoto K
FAU - Morioke, S
AU  - Morioke S
FAU - Okabe, T
AU  - Okabe T
FAU - Kameyoshi, Y
AU  - Kameyoshi Y
FAU - Hide, M
AU  - Hide M
LA  - eng
PT  - Journal Article
DEP - 20091020
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Biomarkers)
RN  - 0 (Fibrin Fibrinogen Degradation Products)
RN  - 0 (fibrin fragment D)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/analysis/*blood
MH  - Blood Coagulation/physiology
MH  - C-Reactive Protein/*analysis
MH  - Child
MH  - Child, Preschool
MH  - Chronic Disease
MH  - Female
MH  - Fibrin Fibrinogen Degradation Products/*analysis
MH  - Fibrinolysis/physiology
MH  - Humans
MH  - Inflammation/*blood/immunology
MH  - Male
MH  - Middle Aged
MH  - Skin Tests
MH  - Urticaria/*blood/immunology
MH  - Young Adult
EDAT- 2009/10/23 06:00
MHDA- 2010/08/21 06:00
CRDT- 2009/10/23 06:00
PHST- 2009/10/23 06:00 [entrez]
PHST- 2009/10/23 06:00 [pubmed]
PHST- 2010/08/21 06:00 [medline]
AID - ALL2222 [pii]
AID - 10.1111/j.1398-9995.2009.02222.x [doi]
PST - ppublish
SO  - Allergy. 2010 May;65(5):649-56. doi: 10.1111/j.1398-9995.2009.02222.x. Epub 2009 
      Oct 20.