PMID- 19845792
OWN - NLM
STAT- MEDLINE
DCOM- 20100819
LR  - 20191210
IS  - 1468-1293 (Electronic)
IS  - 1464-2662 (Linking)
VI  - 11
IP  - 4
DP  - 2010 Apr
TI  - Nonconcordance between subclinical atherosclerosis and the calculated Framingham 
      risk score in HIV-infected patients: relationships with serum markers of 
      oxidation and inflammation.
PG  - 225-31
LID - 10.1111/j.1468-1293.2009.00766.x [doi]
AB  - OBJECTIVES: HIV-infected patients show an increased cardiovascular disease (CVD) 
      risk resulting, essentially, from metabolic disturbances related to chronic 
      infection and antiretroviral treatments. The aims of this study were: (1) to 
      evaluate the agreement between the CVD risk estimated using the Framingham risk 
      score (FRS) and the observed presence of subclinical atherosclerosis in 
      HIV-infected patients; (2) to investigate the relationships between CVD and 
      plasma biomarkers of oxidation and inflammation. METHODS: Atherosclerosis was 
      evaluated in 187 HIV-infected patients by measuring the carotid intima-media 
      thickness (CIMT). CVD risk was estimated using the FRS. We also measured the 
      circulating levels of interleukin-6, monocyte chemoattractant protein-1 (MCP-1) 
      and oxidized low-density lipoprotein (LDL), and paraoxonase-1 activity and 
      concentration. RESULTS: There was a weak, albeit statistically significant, 
      agreement between FRS and CIMT (kappa=0.229, P<0.001). A high proportion of 
      patients with an estimated low risk had subclinical atherosclerosis (n=66; 
      56.4%). In a multivariate analysis, the presence of subclinical atherosclerosis 
      in this subgroup of patients was associated with age [odds ratio (OR) 1.285; 95% 
      confidence interval (CI) 1.084-1.524; P=0.004], body mass index (OR 0.799; 95% CI 
      0.642-0.994; P=0.044), MCP-1 (OR 1.027; 95% CI 1.004-1.050; P=0.020) and oxidized 
      LDL (OR 1.026; 95% CI 1.001-1.051; P=0.041). CONCLUSION: FRS underestimated the 
      presence of subclinical atherosclerosis in HIV-infected patients. The increased 
      CVD risk was related, in part, to the chronic oxidative stress and inflammatory 
      status associated with this patient population.
FAU - Parra, S
AU  - Parra S
AD  - Centre de Recerca Biomedica, Hospital Universitari de Sant Joan, Institut 
      d'Investigacions Sanitaries Pere Virgili, Reus, Spain.
FAU - Coll, B
AU  - Coll B
FAU - Aragones, G
AU  - Aragones G
FAU - Marsillach, J
AU  - Marsillach J
FAU - Beltran, R
AU  - Beltran R
FAU - Rull, A
AU  - Rull A
FAU - Joven, J
AU  - Joven J
FAU - Alonso-Villaverde, C
AU  - Alonso-Villaverde C
FAU - Camps, J
AU  - Camps J
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091021
PL  - England
TA  - HIV Med
JT  - HIV medicine
JID - 100897392
RN  - 0 (Anti-HIV Agents)
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-6)
RN  - 0 (Lipoproteins, LDL)
RN  - 0 (oxidized low density lipoprotein)
RN  - EC 3.1.8.1 (Aryldialkylphosphatase)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Anti-HIV Agents/*adverse effects
MH  - Aryldialkylphosphatase/metabolism
MH  - Atherosclerosis/chemically induced/*complications/pathology
MH  - Biomarkers/blood
MH  - Body Mass Index
MH  - Cardiovascular Diseases/blood/complications/*etiology
MH  - Carotid Arteries/diagnostic imaging/*pathology
MH  - Chemokine CCL2/blood
MH  - Epidemiologic Methods
MH  - Female
MH  - HIV Infections/blood/*complications/drug therapy
MH  - HIV-Associated Lipodystrophy Syndrome/complications/etiology
MH  - Humans
MH  - Interleukin-6/blood
MH  - Lipoproteins, LDL/blood
MH  - Male
MH  - Oxidative Stress
MH  - Tunica Intima/pathology
MH  - Tunica Media/pathology
MH  - Ultrasonography
EDAT- 2009/10/23 06:00
MHDA- 2010/08/20 06:00
CRDT- 2009/10/23 06:00
PHST- 2009/10/23 06:00 [entrez]
PHST- 2009/10/23 06:00 [pubmed]
PHST- 2010/08/20 06:00 [medline]
AID - HIV766 [pii]
AID - 10.1111/j.1468-1293.2009.00766.x [doi]
PST - ppublish
SO  - HIV Med. 2010 Apr;11(4):225-31. doi: 10.1111/j.1468-1293.2009.00766.x. Epub 2009 
      Oct 21.