PMID- 19846414
OWN - NLM
STAT- MEDLINE
DCOM- 20100712
LR  - 20220316
IS  - 1468-2079 (Electronic)
IS  - 0007-1161 (Linking)
VI  - 94
IP  - 5
DP  - 2010 May
TI  - Choroidal filling delay in choroidal neovascularisation due to pathological 
      myopia.
PG  - 611-5
LID - 10.1136/bjo.2009.163535 [doi]
AB  - AIM To assess the choroidal thickness and choroidal circulatory changes in eyes 
      with myopic choroidal neovascularisation (mCNV). METHODS Retrospective, 
      consecutive, observational case series. Forty-two consecutive eyes (17 eyes with 
      newly diagnosed mCNV and 25 eyes without CNV) were included. Choroidal 
      circulation was evaluated by indocyanine green angiography (ICGA), and choroidal 
      thickness was measured by spectral-domain optical coherence tomography (SD-OCT). 
      The factors associated with mCNV were evaluated. RESULTS Sixteen (94%) of 17 eyes 
      with mCNV and six (24%) of 25 eyes without mCNV had well-defined hypofluorescence 
      at the macular region on arterial phase ICGA, that is, a choroidal filling delay. 
      Older age (p<0.001), the presence of a choroidal filling delay (p<0.001) and 
      reduced choroidal thickness (p=0.003) were significantly associated with mCNV on 
      univariate analysis. The most important of these three factors associated with 
      mCNV, in order of importance, were the choroidal filling delay (OR=41.5, p<0.001) 
      and choroidal thickness (per 1 microm, OR=0.97, p=0.01). Older age was 
      significantly associated with both choroidal filling delay (per 1 year, OR=1.16, 
      p<0.001) and choroidal thinning (regression coefficient=-1.22, p<0.001). 
      CONCLUSIONS Significant choroidal changes were observed in eyes with mCNV. 
      Ischaemia-induced growth factor expression caused by decreased choroidal 
      perfusion may be related to the development of mCNV.
FAU - Wakabayashi, Taku
AU  - Wakabayashi T
AD  - Department of Ophthalmology, Osaka University Medical School, Room E7, 2-2 
      Yamadaoka, Suita 565-0871, Osaka, Japan.
FAU - Ikuno, Yasushi
AU  - Ikuno Y
LA  - eng
PT  - Journal Article
DEP - 20091021
PL  - England
TA  - Br J Ophthalmol
JT  - The British journal of ophthalmology
JID - 0421041
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Choroid/*blood supply/pathology
MH  - Choroidal Neovascularization/*etiology/pathology/physiopathology
MH  - Female
MH  - Fluorescein Angiography
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myopia, Degenerative/*complications
MH  - Regional Blood Flow/physiology
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence/methods
MH  - Young Adult
EDAT- 2009/10/23 06:00
MHDA- 2010/07/14 06:00
CRDT- 2009/10/23 06:00
PHST- 2009/10/23 06:00 [entrez]
PHST- 2009/10/23 06:00 [pubmed]
PHST- 2010/07/14 06:00 [medline]
AID - bjo.2009.163535 [pii]
AID - 10.1136/bjo.2009.163535 [doi]
PST - ppublish
SO  - Br J Ophthalmol. 2010 May;94(5):611-5. doi: 10.1136/bjo.2009.163535. Epub 2009 
      Oct 21.