PMID- 19847667
OWN - NLM
STAT- MEDLINE
DCOM- 20100422
LR  - 20211020
IS  - 1875-8312 (Electronic)
IS  - 1569-5794 (Linking)
VI  - 26
IP  - 2
DP  - 2010 Feb
TI  - Predictors of ventricular arrhythmias in patients with mitral valve prolapse.
PG  - 139-45
LID - 10.1007/s10554-009-9514-6 [doi]
AB  - Arrhythmias have been reported to occur frequently in symptomatic patients with 
      mitral valve prolapse (MVP). The mechanisms causing ventricular arrhythmias in 
      patients with MVP have not been fully investigated. The purpose of this study was 
      to determine the clinical, echocardiographic and heart rate variability 
      parameters, and plasma concentrations of electrolytes and inflammatory markers in 
      predicting ventricular arrhythmias in patients with MVP. A total of 58 
      consecutive patients with MVP were included in this study. We performed 
      electrocardiography, echocardiography, holter analysis, routine biochemical tests 
      including plasma concentrations of electrolytes and inflammatory markers, and 
      evaluated the clinical characteristics. Ventricular arrhythmia defined as 
      occurrence of any of the followings: ventricular premature contractions (VPCs), 
      VPC couplets, and ventricular tachycardia documented by holter analysis, 
      continuous monitoring or by electrocardiography. Twenty patients (34%) had 
      ventricular arrhythmias, and 38 (66%) patients had no ventricular arrhythmias. 
      Seventeen patients had VPC, 2 patients had VPC couplets and 1 patient had 
      ventricular tachycardia. Univariable predictors of ventricular arrhythmias 
      included isovolumetric relaxation time and the occurrence of moderate to severe 
      mitral regurgitation. Multivariable logistic regression analysis showed that 
      occurrence of moderate to severe mitral regurgitation was the only independent 
      predictor of ventricular arrhythmias (relative risk: 8.42, 95% confidence 
      interval: 1.49-47.64, p = 0.01). Present study showed that the only independent 
      predictor of ventricular arrhythmias in patients with MVP is the occurrence of 
      moderate to severe mitral regurgitation.
FAU - Turker, Yasin
AU  - Turker Y
AD  - Gulkent State Hospital, Isparta, Turkey.
FAU - Ozaydin, Mehmet
AU  - Ozaydin M
FAU - Acar, Gurkan
AU  - Acar G
FAU - Ozgul, Mustafa
AU  - Ozgul M
FAU - Hoscan, Yesim
AU  - Hoscan Y
FAU - Varol, Ercan
AU  - Varol E
FAU - Dogan, Abdullah
AU  - Dogan A
FAU - Erdogan, Dogan
AU  - Erdogan D
FAU - Yucel, Habil
AU  - Yucel H
LA  - eng
PT  - Journal Article
DEP - 20091022
PL  - United States
TA  - Int J Cardiovasc Imaging
JT  - The international journal of cardiovascular imaging
JID - 100969716
RN  - 0 (Biomarkers)
RN  - 0 (Inflammation Mediators)
SB  - IM
CIN - Int J Cardiovasc Imaging. 2010 Feb;26(2):147-9. PMID: 20175294
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - Chi-Square Distribution
MH  - Echocardiography, Doppler, Color
MH  - Echocardiography, Doppler, Pulsed
MH  - Electrocardiography, Ambulatory
MH  - Female
MH  - Heart Rate
MH  - Humans
MH  - Inflammation Mediators/blood
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Mitral Valve Insufficiency/etiology
MH  - Mitral Valve Prolapse/blood/*complications/diagnosis/physiopathology
MH  - Risk Assessment
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Tachycardia, Ventricular/blood/diagnosis/*etiology/physiopathology
MH  - Ventricular Premature Complexes/blood/diagnosis/*etiology/physiopathology
MH  - Young Adult
EDAT- 2009/10/23 06:00
MHDA- 2010/04/23 06:00
CRDT- 2009/10/23 06:00
PHST- 2009/02/27 00:00 [received]
PHST- 2009/09/16 00:00 [accepted]
PHST- 2009/10/23 06:00 [entrez]
PHST- 2009/10/23 06:00 [pubmed]
PHST- 2010/04/23 06:00 [medline]
AID - 10.1007/s10554-009-9514-6 [doi]
PST - ppublish
SO  - Int J Cardiovasc Imaging. 2010 Feb;26(2):139-45. doi: 10.1007/s10554-009-9514-6. 
      Epub 2009 Oct 22.