PMID- 19850085
OWN - NLM
STAT- MEDLINE
DCOM- 20100413
LR  - 20211020
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Print)
IS  - 0166-4328 (Linking)
VI  - 207
IP  - 2
DP  - 2010 Mar 5
TI  - Short-term total sleep deprivation in the rat increases antioxidant responses in 
      multiple brain regions without impairing spontaneous alternation behavior.
PG  - 305-9
LID - 10.1016/j.bbr.2009.10.014 [doi]
AB  - Total sleep deprivation (TSD) induces a broad spectrum of cognitive, behavioral 
      and cellular changes. We previously reported that long term (5-11 days) TSD in 
      the rat, by the disk-over-water method, decreases the activity of the antioxidant 
      enzyme superoxide dismutase (SOD) in the brainstem and hippocampus. To gain 
      insight into the mechanisms causing cognitive impairment, here we explore the 
      early associations between metabolic activity, antioxidant responses and working 
      memory (one form of cognitive impairment). Specifically we investigated the 
      impact of short-term (6h) TSD, by gentle handling, on the levels of the 
      endogenous antioxidant, total glutathione (GSHt), and the activities of the 
      antioxidative enzymes, SOD and glutathione peroxidase (GPx). Short-term TSD had 
      no significant impact on SOD activity, but increased GSHt levels in the rat 
      cortex, brainstem and basal forebrain, and GPx activity in the rat hippocampus 
      and cerebellum. We also observed increased activity of hexokinase, (HK), the rate 
      limiting enzyme of glucose metabolism, in the rat cortex and hypothalamus. We 
      further showed that 6h of TSD leads to increased exploratory behavior to a new 
      environment, without impairing spontaneous alternation behavior (SAB) in the Y 
      maze. We conclude that acute (6h) sleep loss may trigger compensatory mechanisms 
      (like increased antioxidant responses) that prevent initial deterioration in 
      working memory.
CI  - Published by Elsevier B.V.
FAU - Ramanathan, Lalini
AU  - Ramanathan L
AD  - Neurobiology Research (151A3), Greater Los Angeles Health Care System, North 
      Hills, CA, USA.
FAU - Hu, Shuxin
AU  - Hu S
FAU - Frautschy, Sally A
AU  - Frautschy SA
FAU - Siegel, Jerome M
AU  - Siegel JM
LA  - eng
GR  - IK6 BX005245/BX/BLRD VA/United States
GR  - R37 HL041370/HL/NHLBI NIH HHS/United States
GR  - R01 NS014610/NS/NINDS NIH HHS/United States
GR  - P50 HL060296-100008/HL/NHLBI NIH HHS/United States
GR  - R01 DA034748/DA/NIDA NIH HHS/United States
GR  - R01 MH064109-07/MH/NIMH NIH HHS/United States
GR  - HL-41370/HL/NHLBI NIH HHS/United States
GR  - R01 MH064109/MH/NIMH NIH HHS/United States
GR  - I01 BX001753/BX/BLRD VA/United States
GR  - R37 HL041370-15/HL/NHLBI NIH HHS/United States
GR  - MH-64109/MH/NIMH NIH HHS/United States
GR  - R01 HL041370/HL/NHLBI NIH HHS/United States
GR  - R01 NS069640/NS/NINDS NIH HHS/United States
GR  - P50 HL060296/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20091020
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Antioxidants)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 2.7.1.1 (Hexokinase)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Animals
MH  - Antioxidants/*metabolism
MH  - Behavior, Animal/*physiology
MH  - Brain/enzymology/*physiopathology
MH  - Exploratory Behavior/physiology
MH  - Glutathione/metabolism
MH  - Glutathione Peroxidase/metabolism
MH  - Hexokinase/metabolism
MH  - Male
MH  - Maze Learning/physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sleep Deprivation/enzymology/*physiopathology
MH  - Superoxide Dismutase/metabolism
MH  - Time Factors
PMC - PMC2815069
MID - NIHMS153575
EDAT- 2009/10/24 06:00
MHDA- 2010/04/14 06:00
PMCR- 2011/03/05
CRDT- 2009/10/24 06:00
PHST- 2009/06/30 00:00 [received]
PHST- 2009/10/01 00:00 [revised]
PHST- 2009/10/10 00:00 [accepted]
PHST- 2009/10/24 06:00 [entrez]
PHST- 2009/10/24 06:00 [pubmed]
PHST- 2010/04/14 06:00 [medline]
PHST- 2011/03/05 00:00 [pmc-release]
AID - S0166-4328(09)00608-1 [pii]
AID - 10.1016/j.bbr.2009.10.014 [doi]
PST - ppublish
SO  - Behav Brain Res. 2010 Mar 5;207(2):305-9. doi: 10.1016/j.bbr.2009.10.014. Epub 
      2009 Oct 20.