PMID- 19850681
OWN - NLM
STAT- MEDLINE
DCOM- 20100201
LR  - 20140730
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Linking)
VI  - 95
IP  - 1
DP  - 2010 Jan
TI  - Association of KCNQ1 polymorphisms with the gestational diabetes mellitus in 
      Korean women.
PG  - 445-9
LID - 10.1210/jc.2009-1393 [doi]
AB  - CONTEXT: Similar genetic factors may play role in the pathogenesis of gestational 
      diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM). However, genetic 
      studies on GDM are relatively scarce as compared with T2DM. OBJECTIVE: A recent 
      genome-wide association (GWA) study has proved that three KCNQ1 polymorphisms 
      were significantly associated with the risk of T2DM in various ethnic groups. 
      This study aimed to examine possible genetic effects of these KCNQ1 polymorphisms 
      on the risk of GDM. DESIGN: Three KCNQ1 polymorphisms (rs2074196, rs2237892, and 
      rs2237895) were genotyped using TaqMan assay. The genotype distributions between 
      GDM patients and normal controls were analyzed using logistic regression models. 
      In addition, GDM-related phenotypes were analyzed using multiple regression 
      models. SETTING: All GDM patients recruited from Cheil General Hospital in Seoul, 
      Korea, between 2003 and 2008. PARTICIPANTS: PARTICIPANTS included 930 Korean 
      females with GDM and the data of healthy controls from the previous GWA study. 
      RESULTS: KCNQ1 polymorphisms of rs2237892 and rs2237895 were significantly 
      associated with the risk of GDM (P = 0.003 and 0.005, respectively). In the 
      analyses of the GDM-related phenotype, only the risk allele of KCNQ1 rs2237895 
      was significantly associated with a high-level insulin sensitivity oral glucose 
      tolerance test among patients with GDM (P = 0.0003, 0.004, and 0.05 for 
      codominant, dominant, and recessive models, respectively). CONCLUSION: KCNQ1 
      polymorphisms shown to be associated with increased risk for T2DM in the recent 
      GWA study might also represent genetic factors contributing to the development of 
      GDM in Koreans.
FAU - Shin, Hyoung Doo
AU  - Shin HD
AD  - Department of Genetic Epidemiology, SNP Genetics Inc., Seoul 153-803, Republic of 
      Korea.
FAU - Park, Byung Lae
AU  - Park BL
FAU - Shin, Hui Jin
AU  - Shin HJ
FAU - Kim, Jason Yongha
AU  - Kim JY
FAU - Park, Sunmin
AU  - Park S
FAU - Kim, Bowon
AU  - Kim B
FAU - Kim, Sung-Hoon
AU  - Kim SH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091022
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (KCNQ1 Potassium Channel)
RN  - 0 (KCNQ1 protein, human)
SB  - IM
MH  - Adult
MH  - Diabetes Mellitus, Type 2/genetics/metabolism
MH  - Diabetes, Gestational/*genetics/metabolism
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genome-Wide Association Study
MH  - Humans
MH  - KCNQ1 Potassium Channel/*genetics/metabolism
MH  - Korea
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Pregnancy
MH  - Risk Factors
MH  - Young Adult
EDAT- 2009/10/24 06:00
MHDA- 2010/02/02 06:00
CRDT- 2009/10/24 06:00
PHST- 2009/10/24 06:00 [entrez]
PHST- 2009/10/24 06:00 [pubmed]
PHST- 2010/02/02 06:00 [medline]
AID - jc.2009-1393 [pii]
AID - 10.1210/jc.2009-1393 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2010 Jan;95(1):445-9. doi: 10.1210/jc.2009-1393. Epub 
      2009 Oct 22.