PMID- 19851514
OWN - NLM
STAT- MEDLINE
DCOM- 20100407
LR  - 20211020
IS  - 1178-1998 (Electronic)
IS  - 1176-9092 (Print)
IS  - 1176-9092 (Linking)
VI  - 4
DP  - 2009
TI  - Clinical, radiological, and biochemical characteristics in patients with diseases 
      mimicking polymyalgia rheumatica.
PG  - 391-5
AB  - To find out clues to differentiate between polymyalgia rheumatica (PMR) and other 
      diseases that mimic PMR. We studied Japanese patients with PMR (n = 7), 
      pseudogout (n = 1), remitting seronegative symmetrical synovitis with pitting 
      edema (RS3PE) syndrome (n = 1), and post-infectious polyarthritis (n = 1). The 
      distribution of inflammation in patients was evaluated using a gallium-67 
      scintigraphy. We measured serum C-reactive protein (CRP), matrix 
      metalloproteinase-3 (MMP-3), and vascular endothelial growth factor (VEGF) in 
      patients before and after treatment. Further, we compared the clinical course of 
      PMR with that of other diseases that mimic PMR. Patients with pseudogout, RS3PE 
      syndrome, post-infectious polyarthritis manifested similar changes in 
      scintigraphic findings and serum CRP, MMP-3, and VEGF levels to PMR before the 
      treatment. A significant reduction in serum CRP levels at one week after use of 
      nonsteroidal anti-inflammatory drugs (NSAIDs) is a good clue to differentiate 
      pseudogout and post-infectious polyarthritis from PMR. Chondrocalcinosis in the 
      radiographs of joints is also effective to differentiate pseudogout from PMR. A 
      small reduction of CRP levels after NSAIDs use and promptly ameliorated CRP and 
      symptoms by a low-dose steroid therapy, which was commonly observed in patients 
      with PMR, were also found in a patient with RS3PE syndrome. Pitting edema of the 
      back of hands and gallium uptake in metacarpophalangeal (MCP) joints were useful 
      to differentiate RS3PE syndrome from PMR. In conclusion, pseudogout, RS3PE 
      syndrome, post-infectious polyarthritis should be included in the spectrum of 
      diseases mimicking PMR. A promptly decreased serum CRP level by NSAIDs is a good 
      clue to differentiate pseudogout and post-infectious polyarthritis from PMR. 
      Pitting edema of the back of hands and symmetric gallium uptake in MCP joints are 
      characteristic for RS3PE syndrome.
FAU - Yanai, Hidekatsu
AU  - Yanai H
AD  - Division of General Medicine, Department of Internal Medicine, The Jikei 
      University School of Medicine, Kashiwa, Japan. yanaih@jikei.ac.jp
FAU - Yoshida, Hiroshi
AU  - Yoshida H
FAU - Tada, Norio
AU  - Tada N
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20091012
PL  - New Zealand
TA  - Clin Interv Aging
JT  - Clinical interventions in aging
JID - 101273480
RN  - 0 (Biomarkers)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Japan
MH  - Joint Diseases/*diagnosis/physiopathology
MH  - Male
MH  - Musculoskeletal Diseases/*diagnosis/physiopathology
MH  - Polymyalgia Rheumatica/*diagnosis
PMC - PMC2762363
OTO - NOTNLM
OT  - RS3PE syndrome
OT  - gallium-67 scintigraphy
OT  - polymyalgia rheumatica
OT  - post-infectious polyarthritis
OT  - pseudogout
EDAT- 2009/10/24 06:00
MHDA- 2010/04/08 06:00
PMCR- 2009/10/12
CRDT- 2009/10/24 06:00
PHST- 2009/10/24 06:00 [entrez]
PHST- 2009/10/24 06:00 [pubmed]
PHST- 2010/04/08 06:00 [medline]
PHST- 2009/10/12 00:00 [pmc-release]
AID - cia-4-391 [pii]
AID - 10.2147/cia.s7489 [doi]
PST - ppublish
SO  - Clin Interv Aging. 2009;4:391-5. doi: 10.2147/cia.s7489. Epub 2009 Oct 12.