PMID- 19852949
OWN - NLM
STAT- MEDLINE
DCOM- 20100308
LR  - 20131121
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1307
DP  - 2010 Jan 11
TI  - Effects of a structural analogue of salsolinol, 1-MeDIQ, on pituitary prolactin 
      release and dopaminergic activity in the mediobasal hypothalamus in nursing 
      sheep.
PG  - 72-7
LID - 10.1016/j.brainres.2009.10.033 [doi]
AB  - The prolactin release caused by salsolinol (a derivative of dopamine, DA) in rats 
      could be prevented by its structural analogue 1-methyl-3,4-dihydroisoqinoline 
      (1-MeDIQ). To study the participation of salsolinol in the neural stimulatory 
      mechanism of prolactin release in lactating sheep, we tested whether 1-MeDIQ, 
      acting at the central nervous system (CNS) level, would diminish basal prolactin 
      release and reduce prolactin surge induced by suckling. A series of 
      intracerebroventricular (icv) infusions of 1-MeDIQ (5 x 60 microg/60 microl/30 
      min, at 30-min intervals) were performed in nursing ewes (n=8) during the fifth 
      week of lactation. Additionally, by combining these infusions with push-pull 
      perfusion, we studied the concentration of dopaminergic components, i.e., 
      salsolinol, DA and 3,4-dihydroxyphenylacetic acid (DOPAC) within the infundibular 
      nucleus/median eminence (IN/ME) in four of the ewes. Treatment with 1-MeDIQ 
      significantly (P<0.001) reduced either the basal prolactin release during the 
      non-suckling period or the suckling-induced prolactin surge. Specifically, the 
      suppressive effect occurred gradually, affecting both the duration and amplitude 
      of the prolactin surge. In the control ewes, the perfusate salsolinol 
      concentration increased significantly (P<0.001) during suckling, while in the 
      ewes treated with 1-MeDIQ only vestigial amounts of this compound were found 
      during the non-suckling period. No DA was detected in the perfusates collected 
      from the IN/ME of control and 1-MeDIQ-treated groups and no significant 
      differences were found in the DOPAC concentrations between these groups. In 
      conclusion, 1-MeDIQ is able to inhibit prolactin secretion in lactating sheep, 
      acting at the CNS level. In addition, one of the way of 1-MeDIQ action may be 
      directed to the local salsolinol release within the mediobasal hypothalamus.
FAU - Misztal, Tomasz
AU  - Misztal T
AD  - Department of Endocrinology, The Kielanowski Institute of Animal Physiology and 
      Nutrition, Polish Academy of Sciences, 05-110 Jablonna n/Warsaw, Poland. 
      t.misztal@ifzz.pan.pl
FAU - Gorski, Konrad
AU  - Gorski K
FAU - Tomaszewska-Zaremba, Dorota
AU  - Tomaszewska-Zaremba D
FAU - Fulop, Ferenc
AU  - Fulop F
FAU - Romanowicz, Katarzyna
AU  - Romanowicz K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091021
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (1-methyl-3,4-dihydroisoquinoline)
RN  - 0 (Isoquinolines)
RN  - 102-32-9 (3,4-Dihydroxyphenylacetic Acid)
RN  - 9002-62-4 (Prolactin)
RN  - 9ILS801M65 (salsolinol)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - 3,4-Dihydroxyphenylacetic Acid/metabolism
MH  - Analysis of Variance
MH  - Animals
MH  - Animals, Newborn
MH  - Chromatography, High Pressure Liquid/methods
MH  - Dopamine/*metabolism
MH  - Electrochemistry/methods
MH  - Female
MH  - Hypothalamus, Middle/*drug effects
MH  - Injections, Intraventricular/methods
MH  - Isoquinolines/*pharmacology
MH  - Lactation/*physiology
MH  - Male
MH  - Pituitary Gland/*drug effects
MH  - Prolactin/*blood
MH  - Sheep
MH  - Time Factors
EDAT- 2009/10/27 06:00
MHDA- 2010/03/10 06:00
CRDT- 2009/10/27 06:00
PHST- 2009/07/15 00:00 [received]
PHST- 2009/10/12 00:00 [revised]
PHST- 2009/10/14 00:00 [accepted]
PHST- 2009/10/27 06:00 [entrez]
PHST- 2009/10/27 06:00 [pubmed]
PHST- 2010/03/10 06:00 [medline]
AID - S0006-8993(09)02211-2 [pii]
AID - 10.1016/j.brainres.2009.10.033 [doi]
PST - ppublish
SO  - Brain Res. 2010 Jan 11;1307:72-7. doi: 10.1016/j.brainres.2009.10.033. Epub 2009 
      Oct 21.