PMID- 19853062
OWN - NLM
STAT- MEDLINE
DCOM- 20110126
LR  - 20100531
IS  - 1872-9649 (Electronic)
IS  - 1568-1637 (Linking)
VI  - 9
IP  - 3
DP  - 2010 Jul
TI  - Caloric restriction: from soup to nuts.
PG  - 324-53
LID - 10.1016/j.arr.2009.10.003 [doi]
AB  - Caloric restriction (CR), reduced protein, methionine, or tryptophan diets; and 
      reduced insulin and/or IGFI intracellular signaling can extend mean and/or 
      maximum lifespan and delay deleterious age-related physiological changes in 
      animals. Mice and flies can shift readily between the control and CR 
      physiological states, even at older ages. Many health benefits are induced by 
      even brief periods of CR in flies, rodents, monkeys, and humans. In humans and 
      nonhuman primates, CR produces most of the physiologic, hematologic, hormonal, 
      and biochemical changes it produces in other animals. In primates, CR provides 
      protection from type 2 diabetes, cardiovascular and cerebral vascular diseases, 
      immunological decline, malignancy, hepatotoxicity, liver fibrosis and failure, 
      sarcopenia, inflammation, and DNA damage. It also enhances muscle mitochondrial 
      biogenesis, affords neuroprotection; and extends mean and maximum lifespan. CR 
      rapidly induces antineoplastic effects in mice. Most claims of lifespan extension 
      in rodents by drugs or nutrients are confounded by CR effects. Transcription 
      factors and co-activators involved in the regulation of mitochondrial biogenesis 
      and energy metabolism, including SirT1, PGC-1alpha, AMPK and TOR may be involved 
      in the lifespan effects of CR. Paradoxically, low body weight in middle aged and 
      elderly humans is associated with increased mortality. Thus, enhancement of human 
      longevity may require pharmaceutical interventions.
CI  - 2009 Elsevier Ireland Ltd. All rights reserved.
FAU - Spindler, Stephen R
AU  - Spindler SR
AD  - Department of Biochemistry, University of California, Riverside, Riverside, CA, 
      USA. spindler@ucr.edu
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20091021
PL  - England
TA  - Ageing Res Rev
JT  - Ageing research reviews
JID - 101128963
SB  - IM
MH  - Animals
MH  - *Caloric Restriction
MH  - Diet
MH  - Humans
MH  - Longevity/drug effects/*physiology
RF  - 598
EDAT- 2009/10/27 06:00
MHDA- 2011/01/28 06:00
CRDT- 2009/10/27 06:00
PHST- 2009/08/05 00:00 [received]
PHST- 2009/10/07 00:00 [revised]
PHST- 2009/10/09 00:00 [accepted]
PHST- 2009/10/27 06:00 [entrez]
PHST- 2009/10/27 06:00 [pubmed]
PHST- 2011/01/28 06:00 [medline]
AID - S1568-1637(09)00071-3 [pii]
AID - 10.1016/j.arr.2009.10.003 [doi]
PST - ppublish
SO  - Ageing Res Rev. 2010 Jul;9(3):324-53. doi: 10.1016/j.arr.2009.10.003. Epub 2009 
      Oct 21.