PMID- 19853606
OWN - NLM
STAT- MEDLINE
DCOM- 20100216
LR  - 20211020
IS  - 1090-2430 (Electronic)
IS  - 0014-4886 (Print)
IS  - 0014-4886 (Linking)
VI  - 221
IP  - 1
DP  - 2010 Jan
TI  - Hepatocyte growth factor (HGF) modulates GABAergic inhibition and seizure 
      susceptibility.
PG  - 129-35
LID - 10.1016/j.expneurol.2009.10.011 [doi]
AB  - Disrupted ontogeny of forebrain inhibitory interneurons leads to neurological 
      disorders, including epilepsy. Adult mice lacking the urokinase plasminogen 
      activator receptor (Plaur) have decreased numbers of neocortical GABAergic 
      interneurons and spontaneous seizures, attributed to a reduction of hepatocyte 
      growth factor/scatter factor (HGF/SF). We report that by increasing endogenous 
      HGF/SF concentration in the postnatal Plaur null mouse brain maintains the 
      interneuron populations in the adult, reverses the seizure behavior and 
      stabilizes the spontaneous electroencephalogram activity. The perinatal 
      intervention provides a pathway to reverse potential birth defects and ameliorate 
      seizures in the adult.
FAU - Bae, Mihyun H
AU  - Bae MH
AD  - Department of Anatomy and Neurobiology, University of Maryland School of 
      Medicine, Baltimore, MD 21201, USA.
FAU - Bissonette, Gregory B
AU  - Bissonette GB
FAU - Mars, Wendy M
AU  - Mars WM
FAU - Michalopoulos, George K
AU  - Michalopoulos GK
FAU - Achim, Cristian L
AU  - Achim CL
FAU - Depireux, Didier A
AU  - Depireux DA
FAU - Powell, Elizabeth M
AU  - Powell EM
LA  - eng
GR  - UL1 TR000005/TR/NCATS NIH HHS/United States
GR  - MH57689/MH/NIMH NIH HHS/United States
GR  - R01 MH057683-07/MH/NIMH NIH HHS/United States
GR  - R01 DA018826-04/DA/NIDA NIH HHS/United States
GR  - R01 MH057683/MH/NIMH NIH HHS/United States
GR  - R01 DA018826/DA/NIDA NIH HHS/United States
GR  - DA018826/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20091022
PL  - United States
TA  - Exp Neurol
JT  - Experimental neurology
JID - 0370712
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Parvalbumins)
RN  - 0 (Plaur protein, mouse)
RN  - 0 (Receptors, Urokinase Plasminogen Activator)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - WM5Z385K7T (Pentylenetetrazole)
SB  - IM
MH  - Action Potentials/drug effects/genetics
MH  - Analysis of Variance
MH  - Animals
MH  - Animals, Genetically Modified
MH  - Animals, Newborn
MH  - Avoidance Learning/physiology
MH  - Brain/cytology/metabolism
MH  - Disease Susceptibility/*metabolism
MH  - Electroencephalography/methods
MH  - Enzyme-Linked Immunosorbent Assay/methods
MH  - Glial Fibrillary Acidic Protein/metabolism
MH  - Hepatocyte Growth Factor/*metabolism/pharmacology
MH  - Humans
MH  - Interneurons/drug effects/*physiology
MH  - Mice
MH  - Neural Inhibition/*physiology
MH  - Parvalbumins/metabolism
MH  - Pentylenetetrazole
MH  - Reaction Time/drug effects
MH  - Receptors, Urokinase Plasminogen Activator/genetics
MH  - Seizures/chemically induced/genetics/*metabolism/pathology
MH  - gamma-Aminobutyric Acid/*metabolism
PMC - PMC2812579
MID - NIHMS155609
EDAT- 2009/10/27 06:00
MHDA- 2010/02/17 06:00
PMCR- 2011/01/01
CRDT- 2009/10/27 06:00
PHST- 2009/07/31 00:00 [received]
PHST- 2009/10/10 00:00 [revised]
PHST- 2009/10/15 00:00 [accepted]
PHST- 2009/10/27 06:00 [entrez]
PHST- 2009/10/27 06:00 [pubmed]
PHST- 2010/02/17 06:00 [medline]
PHST- 2011/01/01 00:00 [pmc-release]
AID - S0014-4886(09)00428-2 [pii]
AID - 10.1016/j.expneurol.2009.10.011 [doi]
PST - ppublish
SO  - Exp Neurol. 2010 Jan;221(1):129-35. doi: 10.1016/j.expneurol.2009.10.011. Epub 
      2009 Oct 22.