PMID- 19853884
OWN - NLM
STAT- MEDLINE
DCOM- 20100218
LR  - 20091125
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 78
IP  - 2
DP  - 2010 Jan
TI  - Molecular phylogenies and evolutionary behavior of AhR (aryl hydrocarbon 
      receptor) pathway genes in aquatic animals: implications for the toxicology 
      mechanism of some persistent organic pollutants (POPs).
PG  - 193-205
LID - 10.1016/j.chemosphere.2009.09.012 [doi]
AB  - Phylogenetic analysis of AhR pathway genes and their evolutionary rate variations 
      were studied on aquatic animals. The gene sequences for the proteins involved in 
      this pathway were obtained from four major phylogenetic groups, including 
      bivalvia, amphibian, teleostei and mammalia. These genes were distributed under 
      four major steps of toxicology regulation: formation of cytosolic complex, 
      translocation of AhR, heterodimerization of AhR and induction of CYP1A. The NJ, 
      MP, and ML algorithm were used on protein coding DNA sequences to deduce the 
      evolutionary relationship for the respective AhR pathway gene among different 
      aquatic animals. The rate of non-synonymous nucleotide substitutions per 
      non-synonymous site (d(N)) and synonymous nucleotide substitutions per synonymous 
      site (d(S)) were calculated for different clade of the respective phylogenetic 
      tree for each AhR pathway gene. The phylogenetic analysis suggests that 
      evolutionary pattern of AhR pathway genes in aquatic animals is characterized 
      mainly through gene duplication events or alterative splicing. The d(N) values 
      indicate that all AhR pathway genes are well conserved in aquatic animals, except 
      for CYP1A gene. Furthermore, compare with other aquatic animals, the d(N) value 
      indicates that AhR pathway genes of fish are less conserved, and these genes 
      likely go through an adaptive evolution within aquatic animals.
FAU - Zhou, Hailong
AU  - Zhou H
AD  - Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 
      264003, China.
FAU - Qu, Ying
AU  - Qu Y
FAU - Wu, Huifeng
AU  - Wu H
FAU - Liao, Chunyang
AU  - Liao C
FAU - Zheng, Jiping
AU  - Zheng J
FAU - Diao, Xiaoping
AU  - Diao X
FAU - Xue, Qinzhao
AU  - Xue Q
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091023
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Environmental Pollutants)
RN  - 0 (Receptors, Aryl Hydrocarbon)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP1A1)
SB  - IM
MH  - Algorithms
MH  - Amphibians/genetics
MH  - Animals
MH  - Bivalvia/genetics
MH  - Cytochrome P-450 CYP1A1/metabolism
MH  - Environmental Pollutants/analysis/*toxicity
MH  - Evolution, Molecular
MH  - Mammals/genetics
MH  - Phylogeny
MH  - Receptors, Aryl Hydrocarbon/classification/*genetics/metabolism
EDAT- 2009/10/27 06:00
MHDA- 2010/02/19 06:00
CRDT- 2009/10/27 06:00
PHST- 2009/04/04 00:00 [received]
PHST- 2009/07/15 00:00 [revised]
PHST- 2009/09/03 00:00 [accepted]
PHST- 2009/10/27 06:00 [entrez]
PHST- 2009/10/27 06:00 [pubmed]
PHST- 2010/02/19 06:00 [medline]
AID - S0045-6535(09)01059-5 [pii]
AID - 10.1016/j.chemosphere.2009.09.012 [doi]
PST - ppublish
SO  - Chemosphere. 2010 Jan;78(2):193-205. doi: 10.1016/j.chemosphere.2009.09.012. Epub 
      2009 Oct 23.