PMID- 19854230
OWN - NLM
STAT- MEDLINE
DCOM- 20100422
LR  - 20181211
IS  - 1873-5169 (Electronic)
IS  - 0196-9781 (Linking)
VI  - 31
IP  - 1
DP  - 2010 Jan
TI  - Effects of Endokinin A/B and Endokinin C/D on the modulation of pain in mice.
PG  - 94-100
LID - 10.1016/j.peptides.2009.10.013 [doi]
AB  - Endokinins are novel tachykinins encoded on the human TAC4 and consist of 
      Endokinin A (EKA), B (EKB), C (EKC) and D (EKD). To date, the function of 
      Endokinins in pain processing was not fully understood. Therefore the aim of this 
      study was to investigate the effects of Endokinin A/B (EKA/B, the common 
      C-terminal decapeptide in EKA and EKB) and Endokinin C/D (EKC/D, the common 
      C-terminal duodecapeptide in EKC and EKD) on pain modulation at supraspinal level 
      in mice. Intracerebroventricular (i.c.v.) administration of EKA/B (1, 3, 12, 
      20nmol/mouse) dose dependently induced potent analgesic effect. This effect could 
      be fully antagonized by SR140333B but not SR48968C or SR142801. Naloxone could 
      also block the analgesic effect, suggesting that this analgesic effect is related 
      to opioid receptors. However, i.c.v. administration of EKA/B (10, 30, 
      100pmol/mouse) caused hyperalgesic effect significantly, with a "U" shape curve. 
      Interestingly, the hyperalgesic effect induced by EKA/B could be attenuated by 
      SR140333B, SR142801 but not SR48968C. I.c.v. administration of EKC/D (1, 3, 12, 
      20nmol/mouse) also dose dependently induced analgesic effect, which could not be 
      blocked by SR48968C or SR142801 or naloxone. But to our astonishment, it could be 
      significantly enhanced by SR140333B. More interestingly, the hyperalgesic effect 
      induced by EKA/B could be significantly attenuated by EKC/D. In addition, the 
      analgesic effect induced by co-administration of EKA/B and EKC/D was much less 
      stronger than the effect of either EKA/B or EKC/D.
FAU - Yang, Yinliang
AU  - Yang Y
AD  - Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou 
      University, Lanzhou, China.
FAU - Dong, Shouliang
AU  - Dong S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091023
PL  - United States
TA  - Peptides
JT  - Peptides
JID - 8008690
RN  - 0 (Analgesics)
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Benzamides)
RN  - 0 (Narcotic Antagonists)
RN  - 0 (Peptide Fragments)
RN  - 0 (Piperidines)
RN  - 0 (Receptors, Tachykinin)
RN  - 0 (SR140333B)
RN  - 0 (Tachykinins)
RN  - 0 (Tropanes)
RN  - 0 (endokinin A-B, human)
RN  - 0 (endokinin C-D, human)
RN  - 36B82AMQ7N (Naloxone)
RN  - 720U2QK8I5 (SR 48968)
RN  - K7G81N94DT (SR 142801)
SB  - IM
MH  - Analgesics/administration & dosage/metabolism/*therapeutic use
MH  - Animals
MH  - Antipsychotic Agents/metabolism
MH  - Benzamides/metabolism
MH  - Humans
MH  - Hyperalgesia/chemically induced
MH  - Injections, Intraventricular
MH  - Male
MH  - Mice
MH  - Naloxone/metabolism
MH  - Narcotic Antagonists/metabolism
MH  - Pain/*drug therapy/physiopathology
MH  - Pain Measurement
MH  - Peptide Fragments/administration & dosage/genetics/metabolism/*therapeutic use
MH  - Piperidines/metabolism
MH  - Receptors, Tachykinin/antagonists & inhibitors/metabolism
MH  - Tachykinins/administration & dosage/genetics/metabolism/*therapeutic use
MH  - Tropanes/metabolism
EDAT- 2009/10/27 06:00
MHDA- 2010/04/23 06:00
CRDT- 2009/10/27 06:00
PHST- 2009/08/24 00:00 [received]
PHST- 2009/10/14 00:00 [revised]
PHST- 2009/10/14 00:00 [accepted]
PHST- 2009/10/27 06:00 [entrez]
PHST- 2009/10/27 06:00 [pubmed]
PHST- 2010/04/23 06:00 [medline]
AID - S0196-9781(09)00464-1 [pii]
AID - 10.1016/j.peptides.2009.10.013 [doi]
PST - ppublish
SO  - Peptides. 2010 Jan;31(1):94-100. doi: 10.1016/j.peptides.2009.10.013. Epub 2009 
      Oct 23.