PMID- 19854291
OWN - NLM
STAT- MEDLINE
DCOM- 20100407
LR  - 20220409
IS  - 1873-1635 (Electronic)
IS  - 1350-9462 (Linking)
VI  - 29
IP  - 1
DP  - 2010 Jan
TI  - Polypoidal choroidal vasculopathy and neovascular age-related macular 
      degeneration: same or different disease?
PG  - 19-29
LID - 10.1016/j.preteyeres.2009.10.001 [doi]
AB  - Neovascular age-related macular degeneration (nAMD) is the commonest cause of 
      severe visual impairment in older adults in Caucasian white populations. 
      Polypoidal choroidal vasculopathy (PCV) has been described as a separate clinical 
      entity differing from nAMD and other macular diseases associated with subretinal 
      neovascularization. It remains controversial as to whether or not PCV represents 
      a sub-type of nAMD. This article summarizes the current literature on the 
      clinical, pathophysiological and epidemiological features and treatment responses 
      of PCV and compares this condition to nAMD. Patients with PCV are younger and 
      more likely Asians, and eyes with PCV lack drusen, often present with 
      serosanguinous maculopathy or hemorrhagic pigment epithelial detachment, and have 
      differing responses to photodynamic therapy and anti-vascular endothelial growth 
      factor (VEGF) agents. There are also significant differences in angiographic and 
      optical coherence tomography features between PCV and nAMD. Histopathological 
      studies suggest differences in the anatomical details of the associated vascular 
      abnormalities in the retina and choroids and the relative role of VEGF. There is 
      emerging evidence of common molecular genetic determinants involving complement 
      pathway and common environmental risk factors (e.g. smoking). Such information 
      could further assist clinicians involved in the care of elderly patients with 
      these conditions.
FAU - Laude, Augustinus
AU  - Laude A
AD  - Princess Alexandra Eye Pavilion, NHS Lothian, United Kingdom.
FAU - Cackett, Peter D
AU  - Cackett PD
FAU - Vithana, Eranga N
AU  - Vithana EN
FAU - Yeo, Ian Y
AU  - Yeo IY
FAU - Wong, Doric
AU  - Wong D
FAU - Koh, Adrian H
AU  - Koh AH
FAU - Wong, Tien Y
AU  - Wong TY
FAU - Aung, Tin
AU  - Aung T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20091023
PL  - England
TA  - Prog Retin Eye Res
JT  - Progress in retinal and eye research
JID - 9431859
SB  - IM
MH  - Age Factors
MH  - Choroid/*blood supply/pathology/physiopathology
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Peripheral Vascular Diseases/epidemiology/etiology/*pathology/*physiopathology
MH  - Polyps/*pathology/physiopathology
MH  - Risk Factors
MH  - Wet Macular Degeneration/epidemiology/etiology/*pathology/*physiopathology
RF  - 125
EDAT- 2009/10/27 06:00
MHDA- 2010/04/08 06:00
CRDT- 2009/10/27 06:00
PHST- 2009/10/27 06:00 [entrez]
PHST- 2009/10/27 06:00 [pubmed]
PHST- 2010/04/08 06:00 [medline]
AID - S1350-9462(09)00069-X [pii]
AID - 10.1016/j.preteyeres.2009.10.001 [doi]
PST - ppublish
SO  - Prog Retin Eye Res. 2010 Jan;29(1):19-29. doi: 10.1016/j.preteyeres.2009.10.001. 
      Epub 2009 Oct 23.