PMID- 19855902
OWN - NLM
STAT- MEDLINE
DCOM- 20100712
LR  - 20161018
IS  - 1414-431X (Electronic)
IS  - 0100-879X (Linking)
VI  - 42
IP  - 11
DP  - 2009 Nov
TI  - Peritoneal and serum interleukin-18 levels are not increased in women with 
      minimum or mild endometriosis.
PG  - 1039-43
LID - S0100-879X2009001100007 [pii]
LID - 10.1590/S0100-879X2009001100007 [doi]
AB  - Interleukin-18 (IL-18) is a cytokine that belongs to the IL-1 family. 
      Endometriosis is strongly associated with sub-fertility, and affects about 15% of 
      women of reproductive age. IL-18 may favor the progression of endometriosis. The 
      objective of the present study was to determine the concentration of IL-18 in the 
      serum and peritoneal fluid of infertile women with endometriosis. Forty infertile 
      and 25 fertile women were screened in a teaching hospital. Thirty-four infertile 
      patients with minimal or mild endometriosis and 22 fertile controls were enrolled 
      in the study. The primary outcome was the estimate of IL-18 levels and the 
      secondary outcome was the correlation between serum and peritoneal levels of 
      IL-18. There were no differences between the two groups regarding age, body mass 
      index and levels of peritoneal fluid IL-18 (mean +/- SD): 290.85 +/- 173.02 pg/mL 
      for infertile women vs 374.21 +/- 330.15 pg/mL for controls; or serum IL-18: 
      391.07 +/- 119.71 pg/mL for infertile women vs 373.42 +/- 129.11 pg/mL for 
      controls. However, a positive association was found between serum and peritoneal 
      IL-18 levels in patients with endometriosis: r = 0.794, P = 0.0001. All 
      measurements were carried out at the same time by the Human IL-18 Immuno Assay 
      ELISA kit (MBL Co. Ltd., Japan). The present study did not find evidence 
      supporting the hypothesis that IL-18 levels are associated with infertility in 
      women with minimal and mild endometriosis, although a positive correlation was 
      detected in these women between peritoneal and serum levels of IL-18.
FAU - Glitz, C
AU  - Glitz C
AD  - Departamento de Obstetricia e Ginecologia, Hospital de Clinicas de Porto Alegre, 
      Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, 
      RS, Brasil.
FAU - Souza, C A
AU  - Souza CA
FAU - Rodini, G P
AU  - Rodini GP
FAU - Genro, V
AU  - Genro V
FAU - Bilibio, J P
AU  - Bilibio JP
FAU - Senger, M
AU  - Senger M
FAU - Cunha-Filho, J S
AU  - Cunha-Filho JS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Brazil
TA  - Braz J Med Biol Res
JT  - Brazilian journal of medical and biological research = Revista brasileira de 
      pesquisas medicas e biologicas
JID - 8112917
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Adult
MH  - Ascitic Fluid/*chemistry
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Endometriosis/complications/*metabolism
MH  - Female
MH  - Humans
MH  - Infertility, Female/etiology/*metabolism
MH  - Interleukin-18/*analysis/blood
MH  - Severity of Illness Index
EDAT- 2009/10/27 06:00
MHDA- 2010/07/14 06:00
CRDT- 2009/10/27 06:00
PHST- 2009/04/16 00:00 [received]
PHST- 2009/09/23 00:00 [accepted]
PHST- 2009/10/27 06:00 [entrez]
PHST- 2009/10/27 06:00 [pubmed]
PHST- 2010/07/14 06:00 [medline]
AID - S0100-879X2009001100007 [pii]
AID - 10.1590/S0100-879X2009001100007 [doi]
PST - ppublish
SO  - Braz J Med Biol Res. 2009 Nov;42(11):1039-43. doi: 
      10.1590/S0100-879X2009001100007.