PMID- 19856417
OWN - NLM
STAT- MEDLINE
DCOM- 20100121
LR  - 20211020
IS  - 1522-2586 (Electronic)
IS  - 1053-1807 (Print)
IS  - 1053-1807 (Linking)
VI  - 30
IP  - 5
DP  - 2009 Nov
TI  - Shorter difference between myocardium and blood optimal inversion time suggests 
      diffuse fibrosis in dilated cardiomyopathy.
PG  - 967-72
LID - 10.1002/jmri.21953 [doi]
AB  - PURPOSE: To find evidence of diffuse fibrosis in dilated cardiomyopathy (DCM) 
      patients by comparing measurements on clinical late gadolinium enhancement (LGE) 
      cardiovascular magnetic resonance (CMR) studies between DCM and healthy subjects. 
      MATERIALS AND METHODS: LGE-CMR and the Look-Locker images from 20 DCM patients 
      and 17 healthy controls were analyzed. Blood signal-to-noise ratio (SNR), 
      myocardium SNR, and blood-to-myocardium contrast-to-noise ratio (CNR) were 
      measured on the LGE-CMR images. The optimal inversion time (TI) to null blood and 
      myocardium was determined on the Look-Locker images. The postcontrast T(1) was 
      estimated using a phantom study that correlated optimal TI and heart rate to 
      T(1). RESULTS: The blood SNR was lower, myocardium SNR was higher, and the 
      blood-to-myocardium CNR was lower (6.6 +/- 0.7 vs. 10.3 +/- 0.9, P = 0.004) on 
      DCM LGE-CMR images as compared to controls. The blood-myocardium optimal TI 
      difference (DeltaTI) was lower (38 +/- 2 msec vs. 55 +/- 3 msec, P < 0.001) in 
      DCM, and the estimated blood-myocardium T(1) difference (DeltaT(1)) (116 +/- 6 
      msec vs. 152 +/- 8 msec, P = 0.001) was also lower. CONCLUSION: DCM patients have 
      reduced blood-myocardium DeltaTI and DeltaT(1), and lower CNR as compared to 
      controls, suggesting the presence of diffuse fibrosis. This may impact the 
      interpretation of LGE data.
FAU - Han, Yuchi
AU  - Han Y
AD  - Department of Medicine, Cardiovascular Division, Beth Israel Deaconess Medical 
      Center, Harvard Medical School, Boston, Massachusetts 02215, USA. 
      yhan@bidmc.harvard.edu
FAU - Peters, Dana C
AU  - Peters DC
FAU - Dokhan, Basem
AU  - Dokhan B
FAU - Manning, Warren J
AU  - Manning WJ
LA  - eng
GR  - K01 EB004434/EB/NIBIB NIH HHS/United States
GR  - K01 EB004434-05/EB/NIBIB NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Magn Reson Imaging
JT  - Journal of magnetic resonance imaging : JMRI
JID - 9105850
RN  - 0 (Contrast Media)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Aged
MH  - Cardiomyopathy, Dilated/*pathology
MH  - Case-Control Studies
MH  - Contrast Media/pharmacology
MH  - Female
MH  - Fibrosis/*pathology
MH  - Gadolinium/*pharmacology
MH  - Humans
MH  - Image Processing, Computer-Assisted/methods
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*pathology
MH  - Time Factors
MH  - Ventricular Function, Left
PMC - PMC2862561
MID - NIHMS185604
EDAT- 2009/10/27 06:00
MHDA- 2010/01/22 06:00
PMCR- 2010/11/01
CRDT- 2009/10/27 06:00
PHST- 2009/10/27 06:00 [entrez]
PHST- 2009/10/27 06:00 [pubmed]
PHST- 2010/01/22 06:00 [medline]
PHST- 2010/11/01 00:00 [pmc-release]
AID - 10.1002/jmri.21953 [doi]
PST - ppublish
SO  - J Magn Reson Imaging. 2009 Nov;30(5):967-72. doi: 10.1002/jmri.21953.