PMID- 19857389
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20100609
LR  - 20211020
IS  - 1534-3146 (Electronic)
IS  - 1523-3847 (Linking)
VI  - 11
IP  - 6
DP  - 2009 Nov
TI  - Update on immune reconstitution inflammatory syndrome: progress and unanswered 
      questions.
PG  - 486-93
AB  - The immune reconstitution inflammatory syndrome (IRIS) is characterized by 
      clinical deterioration occurring after the initiation of effective antiretroviral 
      therapy (ART) and results from a disordered and exuberant immune response. The 
      syndrome may present as paradoxical IRIS or unmasking IRIS, depending on whether 
      an opportunistic infection was recognized and treated before ART initiation. 
      Numerous descriptions of IRIS caused by many pathogens were published in the 
      years after the introduction of effective ART. In recent years, with enhanced 
      rollout of ART in resource-limited settings, attention has again focused on IRIS 
      because of the enormous burden of opportunistic infections. This review 
      highlights recent findings elucidating risk factors for and the pathogenesis and 
      treatment of IRIS.
FAU - Kelley, Colleen F
AU  - Kelley CF
AD  - Division of Infectious Disease, Department of Medicine, Emory University School 
      of Medicine, 341 Ponce de Leon Avenue, Atlanta, GA 30308, USA.
FAU - Armstrong, Wendy S
AU  - Armstrong WS
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Curr Infect Dis Rep
JT  - Current infectious disease reports
JID - 100888983
EDAT- 2009/10/28 06:00
MHDA- 2009/10/28 06:01
CRDT- 2009/10/28 06:00
PHST- 2009/10/28 06:00 [entrez]
PHST- 2009/10/28 06:00 [pubmed]
PHST- 2009/10/28 06:01 [medline]
AID - 10.1007/s11908-009-0070-y [doi]
PST - ppublish
SO  - Curr Infect Dis Rep. 2009 Nov;11(6):486-93. doi: 10.1007/s11908-009-0070-y.