PMID- 19860590
OWN - NLM
STAT- MEDLINE
DCOM- 20100607
LR  - 20091028
IS  - 1532-4311 (Electronic)
IS  - 0882-0139 (Linking)
VI  - 38
IP  - 8
DP  - 2009
TI  - The frequency of HLA class I and II alleles in Pakistani patients with aplastic 
      anemia.
PG  - 812-9
LID - 10.3109/08820130903271415 [doi]
AB  - Hematological disorders like Aplastic anemia are quite frequent in Pakistan. 
      Human leukocyte antigen (HLA) system, have been implicated in the development of 
      Aplastic anemia in various population-based studies, The aim of this study was to 
      determine the role of the HLA Class I and Class II alleles in genetic 
      susceptibility to Aplastic anemia in Pakistani patients. HLA A*, B* and DRB1* 
      alleles were analyzed, in 61 Pakistani patients (Females n = 22, Males n = 39) 
      and the control group consisted of 200 ethnically matched individuals (Females n 
      = 89, Males n = 111). The allele frequency of DRB1*15 was found significantly 
      higher in patients 0.36 (p = 0.001 with odds ratio = 1.97), as compared to the 
      controls 0.212. Although DRB1*03 percent frequency was significantly higher in 
      controls 0.175 (p = 0.023) with odds ratio = 0.514, as compared to patients 
      0.106.Therefore DRB1*15 emerged as a susceptible allele and DRB1*03 as a 
      protective allele in Pakistani Aplastic anemia patients and control samples. No 
      significant difference was found in allele frequencies of other HLA class I and 
      HLA class II alleles for both patients and controls. Three haplotypes A*02 B*40 
      DRB1*15 (p = 0.021), A*31 B*51 DRB1*13 (p = 0.12) and A*33 B*58 DRB1*15 (p = 
      0.000) showed significant variations in the two groups.
FAU - Rehman, Sadia
AU  - Rehman S
AD  - Institute of Biomedical and Genetic Engineering Division Dr A Q Khan Research 
      Laboratories, Islamabad, Pakistan. sadiatr@yahoo.com
FAU - Saba, Nusrat
AU  - Saba N
FAU - Khalilullah
AU  - Khalilullah
FAU - Munir, Saeeda
AU  - Munir S
FAU - Ahmed, Parvez
AU  - Ahmed P
FAU - Mehmood, Tariq
AU  - Mehmood T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Immunol Invest
JT  - Immunological investigations
JID - 8504629
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR1 Antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anemia, Aplastic/*genetics/immunology/metabolism
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - *Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - HLA-A Antigens/*genetics/immunology
MH  - HLA-B Antigens/*genetics/immunology
MH  - HLA-DR1 Antigen/*genetics/immunology
MH  - Humans
MH  - Infant
MH  - Male
MH  - Middle Aged
MH  - Pakistan
MH  - Polymorphism, Genetic
EDAT- 2009/10/29 06:00
MHDA- 2010/06/09 06:00
CRDT- 2009/10/29 06:00
PHST- 2009/10/29 06:00 [entrez]
PHST- 2009/10/29 06:00 [pubmed]
PHST- 2010/06/09 06:00 [medline]
AID - 10.3109/08820130903271415 [pii]
AID - 10.3109/08820130903271415 [doi]
PST - ppublish
SO  - Immunol Invest. 2009;38(8):812-9. doi: 10.3109/08820130903271415.