PMID- 19861018
OWN - NLM
STAT- MEDLINE
DCOM- 20100107
LR  - 20161125
IS  - 1815-7920 (Electronic)
IS  - 1027-3719 (Linking)
VI  - 13
IP  - 11
DP  - 2009 Nov
TI  - QuantiFERON-TB Gold in the identification of latent tuberculosis infection in 
      rheumatoid arthritis: a pilot study.
PG  - 1427-32
AB  - OBJECTIVE: To compare the performance of QuantiFERON-TB Gold (QFT-G) with that of 
      the tuberculin skin test (TST) in detecting latent tuberculosis (LTBI) among 
      patients with rheumatoid arthritis (RA). PATIENTS AND METHODS: A total of 35 RA 
      patients and 15 healthy controls underwent TST, QFT-G assays and chest X-ray and 
      filled out a questionnaire on predisposing conditions for TB disease. Serum 
      interferon gamma (IFN-gamma) levels were tested by an enzyme-linked immunosorbent 
      assay. RESULTS: Forty-five per cent of RA patients had a TST > 5 mm vs. 26% in 
      healthy controls. In the RA patients, QFT-G was positive in 11.4%, negative in 
      60% and indeterminate in 28.6%. The overall agreement between TST and QFT-G was 
      significantly lower in the RA population than in controls (56% vs. 84%). No 
      correlation was found between the use of prednisone, methotrexate and QFT-G 
      results or agreement between TST and QFT-G. A low IFN-gamma level (<4 pg/ml) was 
      found in 51.5% of the RA patients. No correlation was found between serum 
      IFN-gamma levels and QFT-G results. CONCLUSION: The clinical significance of 
      negative QFT-G in TST-positive patients with low TB risk remains to be assessed. 
      The high rate of indeterminate results questions the clinical utility of QFT-G in 
      the diagnosis of LTBI in RA patients.
FAU - Shovman, O
AU  - Shovman O
AD  - Department of Rheumatology, Tel Aviv Medical Center, Tel Aviv, Israel.
FAU - Anouk, M
AU  - Anouk M
FAU - Vinnitsky, N
AU  - Vinnitsky N
FAU - Arad, U
AU  - Arad U
FAU - Paran, D
AU  - Paran D
FAU - Litinsky, I
AU  - Litinsky I
FAU - Caspi, D
AU  - Caspi D
FAU - Elkayam, O
AU  - Elkayam O
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - France
TA  - Int J Tuberc Lung Dis
JT  - The international journal of tuberculosis and lung disease : the official journal 
      of the International Union against Tuberculosis and Lung Disease
JID - 9706389
RN  - 0 (Antirheumatic Agents)
RN  - 0 (Biomarkers)
RN  - 0 (Reagent Kits, Diagnostic)
RN  - 82115-62-6 (Interferon-gamma)
RN  - VB0R961HZT (Prednisone)
RN  - YL5FZ2Y5U1 (Methotrexate)
SB  - IM
MH  - Antirheumatic Agents/therapeutic use
MH  - Arthritis, Rheumatoid/*complications/drug therapy
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - *Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Interferon-gamma/*blood
MH  - Latent Tuberculosis/*diagnosis/diagnostic imaging/microbiology
MH  - Male
MH  - Methotrexate/therapeutic use
MH  - Middle Aged
MH  - Mycobacterium/*immunology
MH  - Pilot Projects
MH  - Predictive Value of Tests
MH  - Prednisone/therapeutic use
MH  - Radiography
MH  - *Reagent Kits, Diagnostic
MH  - Surveys and Questionnaires
MH  - *Tuberculin Test
EDAT- 2009/10/29 06:00
MHDA- 2010/01/08 06:00
CRDT- 2009/10/29 06:00
PHST- 2009/10/29 06:00 [entrez]
PHST- 2009/10/29 06:00 [pubmed]
PHST- 2010/01/08 06:00 [medline]
PST - ppublish
SO  - Int J Tuberc Lung Dis. 2009 Nov;13(11):1427-32.