PMID- 19862010
OWN - NLM
STAT- MEDLINE
DCOM- 20091130
LR  - 20211028
IS  - 1546-1718 (Electronic)
IS  - 1061-4036 (Print)
IS  - 1061-4036 (Linking)
VI  - 41
IP  - 11
DP  - 2009 Nov
TI  - Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.
PG  - 1191-8
LID - 10.1038/ng.466 [doi]
AB  - Measurements of erythrocytes within the blood are important clinical traits and 
      can indicate various hematological disorders. We report here genome-wide 
      association studies (GWAS) for six erythrocyte traits, including hemoglobin 
      concentration (Hb), hematocrit (Hct), mean corpuscular volume (MCV), mean 
      corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC) 
      and red blood cell count (RBC). We performed an initial GWAS in cohorts of the 
      CHARGE Consortium totaling 24,167 individuals of European ancestry and 
      replication in additional independent cohorts of the HaemGen Consortium totaling 
      9,456 individuals. We identified 23 loci significantly associated with these 
      traits in a meta-analysis of the discovery and replication cohorts (combined P 
      values ranging from 5 x 10(-8) to 7 x 10(-86)). Our findings include loci 
      previously associated with these traits (HBS1L-MYB, HFE, TMPRSS6, TFR2, SPTA1) as 
      well as new associations (EPO, TFRC, SH2B3 and 15 other loci). This study has 
      identified new determinants of erythrocyte traits, offering insight into common 
      variants underlying variation in erythrocyte measures.
FAU - Ganesh, Santhi K
AU  - Ganesh SK
AD  - National Human Genome Research Institute, Division of Intramural Research, 
      Bethesda, MD, USA. ganeshs@mail.nih.gov
FAU - Zakai, Neil A
AU  - Zakai NA
FAU - van Rooij, Frank J A
AU  - van Rooij FJ
FAU - Soranzo, Nicole
AU  - Soranzo N
FAU - Smith, Albert V
AU  - Smith AV
FAU - Nalls, Michael A
AU  - Nalls MA
FAU - Chen, Ming-Huei
AU  - Chen MH
FAU - Kottgen, Anna
AU  - Kottgen A
FAU - Glazer, Nicole L
AU  - Glazer NL
FAU - Dehghan, Abbas
AU  - Dehghan A
FAU - Kuhnel, Brigitte
AU  - Kuhnel B
FAU - Aspelund, Thor
AU  - Aspelund T
FAU - Yang, Qiong
AU  - Yang Q
FAU - Tanaka, Toshiko
AU  - Tanaka T
FAU - Jaffe, Andrew
AU  - Jaffe A
FAU - Bis, Joshua C M
AU  - Bis JC
FAU - Verwoert, Germaine C
AU  - Verwoert GC
FAU - Teumer, Alexander
AU  - Teumer A
FAU - Fox, Caroline S
AU  - Fox CS
FAU - Guralnik, Jack M
AU  - Guralnik JM
FAU - Ehret, Georg B
AU  - Ehret GB
FAU - Rice, Kenneth
AU  - Rice K
FAU - Felix, Janine F
AU  - Felix JF
FAU - Rendon, Augusto
AU  - Rendon A
FAU - Eiriksdottir, Gudny
AU  - Eiriksdottir G
FAU - Levy, Daniel
AU  - Levy D
FAU - Patel, Kushang V
AU  - Patel KV
FAU - Boerwinkle, Eric
AU  - Boerwinkle E
FAU - Rotter, Jerome I
AU  - Rotter JI
FAU - Hofman, Albert
AU  - Hofman A
FAU - Sambrook, Jennifer G
AU  - Sambrook JG
FAU - Hernandez, Dena G
AU  - Hernandez DG
FAU - Zheng, Gang
AU  - Zheng G
FAU - Bandinelli, Stefania
AU  - Bandinelli S
FAU - Singleton, Andrew B
AU  - Singleton AB
FAU - Coresh, Josef
AU  - Coresh J
FAU - Lumley, Thomas
AU  - Lumley T
FAU - Uitterlinden, Andre G
AU  - Uitterlinden AG
FAU - Vangils, Janine M
AU  - Vangils JM
FAU - Launer, Lenore J
AU  - Launer LJ
FAU - Cupples, L Adrienne
AU  - Cupples LA
FAU - Oostra, Ben A
AU  - Oostra BA
FAU - Zwaginga, Jaap-Jan
AU  - Zwaginga JJ
FAU - Ouwehand, Willem H
AU  - Ouwehand WH
FAU - Thein, Swee-Lay
AU  - Thein SL
FAU - Meisinger, Christa
AU  - Meisinger C
FAU - Deloukas, Panos
AU  - Deloukas P
FAU - Nauck, Matthias
AU  - Nauck M
FAU - Spector, Tim D
AU  - Spector TD
FAU - Gieger, Christian
AU  - Gieger C
FAU - Gudnason, Vilmundur
AU  - Gudnason V
FAU - van Duijn, Cornelia M
AU  - van Duijn CM
FAU - Psaty, Bruce M
AU  - Psaty BM
FAU - Ferrucci, Luigi
AU  - Ferrucci L
FAU - Chakravarti, Aravinda
AU  - Chakravarti A
FAU - Greinacher, Andreas
AU  - Greinacher A
FAU - O'Donnell, Christopher J
AU  - O'Donnell CJ
FAU - Witteman, Jacqueline C M
AU  - Witteman JC
FAU - Furth, Susan
AU  - Furth S
FAU - Cushman, Mary
AU  - Cushman M
FAU - Harris, Tamara B
AU  - Harris TB
FAU - Lin, Jing-Ping
AU  - Lin JP
LA  - eng
GR  - P30 DK063491-05/DK/NIDDK NIH HHS/United States
GR  - U01 DK066174/DK/NIDDK NIH HHS/United States
GR  - R01 HL086694/HL/NHLBI NIH HHS/United States
GR  - G0000111/MRC_/Medical Research Council/United Kingdom
GR  - R01 HL086694-01A1/HL/NHLBI NIH HHS/United States
GR  - P30 DK063491-039004/DK/NIDDK NIH HHS/United States
GR  - R01 HL086694-03/HL/NHLBI NIH HHS/United States
GR  - P30 DK063491-029004/DK/NIDDK NIH HHS/United States
GR  - P30 DK063491-019004/DK/NIDDK NIH HHS/United States
GR  - P30 DK063491-049004/DK/NIDDK NIH HHS/United States
GR  - K24 DK078737/DK/NIDDK NIH HHS/United States
GR  - P30 DK063491/DK/NIDDK NIH HHS/United States
GR  - R01 HL086694-02/HL/NHLBI NIH HHS/United States
PT  - Journal Article
DEP - 20091011
PL  - United States
TA  - Nat Genet
JT  - Nature genetics
JID - 9216904
SB  - IM
CIN - Nat Genet. 2009 Nov;41(11):1161-2. PMID: 19862006
MH  - Blood Pressure/*genetics
MH  - Cell Line
MH  - Cohort Studies
MH  - Endothelial Cells/metabolism
MH  - *Erythrocytes/metabolism
MH  - Gene Expression
MH  - Genome, Human
MH  - *Genome-Wide Association Study
MH  - Humans
MH  - Hypertension/*genetics
MH  - *Phenotype
MH  - Polymorphism, Single Nucleotide
MH  - Quantitative Trait Loci
PMC - PMC2778265
MID - NIHMS145796
EDAT- 2009/10/29 06:00
MHDA- 2009/12/16 06:00
PMCR- 2010/05/01
CRDT- 2009/10/29 06:00
PHST- 2009/08/07 00:00 [received]
PHST- 2009/09/01 00:00 [accepted]
PHST- 2009/10/29 06:00 [entrez]
PHST- 2009/10/29 06:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
PHST- 2010/05/01 00:00 [pmc-release]
AID - ng.466 [pii]
AID - 10.1038/ng.466 [doi]
PST - ppublish
SO  - Nat Genet. 2009 Nov;41(11):1191-8. doi: 10.1038/ng.466. Epub 2009 Oct 11.