PMID- 19863884
OWN - NLM
STAT- MEDLINE
DCOM- 20100113
LR  - 20190608
IS  - 0301-0430 (Print)
IS  - 0301-0430 (Linking)
VI  - 72
IP  - 5
DP  - 2009 Nov
TI  - Evolution of light chain deposition disease over 8 years.
PG  - 397-401
AB  - A 44-year-old female was diagnosed with proteinuria due to nodular 
      glomerulosclerosis secondary to light chain deposition disease (LCDD). After 6 
      years, deterioration of kidney function occurred and autologous stem cell 
      transplantation was considered, but the patient refused specific therapies. The 
      disease progressed slowly, over a period of 8 years reaching now chronic renal 
      insufficiency stage 4 with a creatinine clearance of 20 ml/min, in spite of no 
      specific therapy. This case, documented by repeated biopsies, demonstrates the 
      very slow loss of kidney function, suggesting the possibility of conservative 
      treatment strategies without taking the risks of chemotherapy or autologous stem 
      cell transplantation, since no long term follow up data of these therapies are 
      available for LCDD.
FAU - Gerth, J
AU  - Gerth J
AD  - Department of Internal Medicine III of the Friedrich-Schiller-University Jena, 
      Jena, Germany.
FAU - Busch, M
AU  - Busch M
FAU - Ott, U
AU  - Ott U
FAU - Groene, H-J
AU  - Groene HJ
FAU - Wolf, G
AU  - Wolf G
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Germany
TA  - Clin Nephrol
JT  - Clinical nephrology
JID - 0364441
RN  - 0 (Immunoglobulin Light Chains)
SB  - IM
MH  - Adult
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Immunoglobulin Light Chains/*analysis
MH  - Kidney/pathology
MH  - Kidney Diseases/*immunology/pathology/therapy
MH  - Kidney Failure, Chronic/etiology
EDAT- 2009/10/30 06:00
MHDA- 2010/01/14 06:00
CRDT- 2009/10/30 06:00
PHST- 2009/10/30 06:00 [entrez]
PHST- 2009/10/30 06:00 [pubmed]
PHST- 2010/01/14 06:00 [medline]
AID - 6745 [pii]
AID - 10.5414/cnp72397 [doi]
PST - ppublish
SO  - Clin Nephrol. 2009 Nov;72(5):397-401. doi: 10.5414/cnp72397.