PMID- 19865074
OWN - NLM
STAT- MEDLINE
DCOM- 20101217
LR  - 20161125
IS  - 1559-064X (Electronic)
IS  - 1559-0631 (Linking)
VI  - 20
IP  - 7
DP  - 2010 Nov
TI  - Maternal exposure to perfluorinated acids and fetal growth.
PG  - 589-97
LID - 10.1038/jes.2009.57 [doi]
AB  - The widespread detection of perfluorinated acids (PFAs) in humans and known 
      developmental toxicity in animals has raised concern about their potential 
      effects on human reproductive health. Our objective was to determine whether 
      increasing maternal exposure to PFAs is associated with adverse effects on fetal 
      growth and length of gestation in women giving birth in Alberta, Canada. We 
      examined the concentrations of perfluorooctanoic acid (PFOA), perfluorooctane 
      sulfonate (PFOS), and perfluorohexane sulfonate (PFHxS) in a cohort of 252 
      pregnant women who gave birth to live singletons. Each of the women had undergone 
      an early second trimester prenatal screen, and her serum was analyzed for PFA 
      concentrations. Data on infant and maternal variables were collected from the 
      delivery record completed at birth. Adjusted changes in birth weight per natural 
      log (ng/ml) of PFOA (median 1.5 ng/ml), PFHxS (median 0.97 ng/ml), and PFOS 
      (median 7.8 ng/ml) were -37.4 g (95% confidence interval (CI): -86.0 to 11.2 g), 
      21.9 g (-23.4 to 67.2 g), and 31.3 g (-43.3 to 105.9 g), respectively. Mean birth 
      weight z-score, standardized for gestational age and gender, length of gestation, 
      and risk of preterm birth did not appear to be influenced by maternal PFA 
      exposure. When PFA concentrations were divided into tertiles, similar patterns 
      were observed. These results suggest that maternal PFA exposure has no 
      substantial effect on fetal weight and length of gestation at the concentrations 
      observed in this population.
FAU - Hamm, Michele P
AU  - Hamm MP
AD  - Department of Public Health Sciences, School of Public Health, University of 
      Alberta, Edmonton, Alberta, Canada.
FAU - Cherry, Nicola M
AU  - Cherry NM
FAU - Chan, Emily
AU  - Chan E
FAU - Martin, Jonathan W
AU  - Martin JW
FAU - Burstyn, Igor
AU  - Burstyn I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091028
PL  - United States
TA  - J Expo Sci Environ Epidemiol
JT  - Journal of exposure science & environmental epidemiology
JID - 101262796
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Caprylates)
RN  - 0 (Fluorocarbons)
RN  - 0 (Sulfonic Acids)
RN  - 355-46-4 (perfluorohexanesulfonic acid)
RN  - 947VD76D3L (perfluorooctanoic acid)
RN  - 9H2MAI21CL (perfluorooctane sulfonic acid)
SB  - IM
MH  - Alkanesulfonic Acids/adverse effects/blood
MH  - Birth Weight/drug effects
MH  - Caprylates/adverse effects/blood
MH  - Cohort Studies
MH  - Female
MH  - Fetal Development/*drug effects
MH  - Fluorocarbons/*adverse effects/blood
MH  - Gestational Age
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Small for Gestational Age
MH  - Linear Models
MH  - Male
MH  - Maternal Exposure/*adverse effects
MH  - Poisson Distribution
MH  - Pregnancy
MH  - Sulfonic Acids/adverse effects/blood
EDAT- 2009/10/30 06:00
MHDA- 2010/12/18 06:00
CRDT- 2009/10/30 06:00
PHST- 2009/10/30 06:00 [entrez]
PHST- 2009/10/30 06:00 [pubmed]
PHST- 2010/12/18 06:00 [medline]
AID - jes200957 [pii]
AID - 10.1038/jes.2009.57 [doi]
PST - ppublish
SO  - J Expo Sci Environ Epidemiol. 2010 Nov;20(7):589-97. doi: 10.1038/jes.2009.57. 
      Epub 2009 Oct 28.