PMID- 19865101
OWN - NLM
STAT- MEDLINE
DCOM- 20100614
LR  - 20121115
IS  - 1476-5470 (Electronic)
IS  - 1466-4879 (Linking)
VI  - 11
IP  - 2
DP  - 2010 Mar
TI  - Genetic variants of CC chemokine genes in experimental autoimmune 
      encephalomyelitis, multiple sclerosis and rheumatoid arthritis.
PG  - 142-54
LID - 10.1038/gene.2009.82 [doi]
AB  - Multiple sclerosis (MS) is a complex disorder of the central nervous system, 
      causing inflammation, demyelination and axonal damage. A limited number of 
      genetic risk factors for MS have been identified, but the etiology of the disease 
      remains largely unknown. For the identification of genes regulating 
      neuroinflammation we used a rat model of MS, myelin oligodendrocyte glycoprotein 
      (MOG)-induced experimental autoimmune encephalomyelitis (EAE), and carried out a 
      linkage analysis in an advanced intercross line (AIL). We thereby redefine the 
      Eae18b locus to a 0.88 Mb region, including a cluster of chemokine genes. 
      Further, we show differential expression of Ccl2, Ccl11 and Ccl11 during EAE in 
      rat strains with opposite susceptibility to EAE, regulated by genotype in Eae18b. 
      The human homologous genes were tested for association to MS in 3841 cases and 
      4046 controls from four Nordic countries. A haplotype in CCL2 and rs3136682 in 
      CCL1 show a protective association to MS, whereas a haplotype in CCL13 is disease 
      predisposing. In the HLA-DRB1* 15 positive subgroup, we also identified an 
      association to a risk haplotype in CCL2, suggesting an influence from the human 
      leukocyte antigen (HLA) locus. We further identified association to rheumatoid 
      arthritis in CCL2, CCL8 and CCL13, indicating common regulatory mechanisms for 
      complex diseases.
FAU - Ockinger, J
AU  - Ockinger J
AD  - Neuroimmunology Unit, Department of Clinical Neuroscience, Center of Molecular 
      Medicine, Karolinska Institutet, Stockholm, Sweden. johan.ockinger@ki.se
FAU - Stridh, P
AU  - Stridh P
FAU - Beyeen, A D
AU  - Beyeen AD
FAU - Lundmark, F
AU  - Lundmark F
FAU - Seddighzadeh, M
AU  - Seddighzadeh M
FAU - Oturai, A
AU  - Oturai A
FAU - Sorensen, P S
AU  - Sorensen PS
FAU - Lorentzen, A R
AU  - Lorentzen AR
FAU - Celius, E G
AU  - Celius EG
FAU - Leppa, V
AU  - Leppa V
FAU - Koivisto, K
AU  - Koivisto K
FAU - Tienari, P J
AU  - Tienari PJ
FAU - Alfredsson, L
AU  - Alfredsson L
FAU - Padyukov, L
AU  - Padyukov L
FAU - Hillert, J
AU  - Hillert J
FAU - Kockum, I
AU  - Kockum I
FAU - Jagodic, M
AU  - Jagodic M
FAU - Olsson, T
AU  - Olsson T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091029
PL  - England
TA  - Genes Immun
JT  - Genes and immunity
JID - 100953417
RN  - 0 (Chemokines)
RN  - 0 (Chemokines, CC)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (MOG protein, human)
RN  - 0 (Mog protein, mouse)
RN  - 0 (Mog protein, rat)
RN  - 0 (Myelin Proteins)
RN  - 0 (Myelin-Associated Glycoprotein)
RN  - 0 (Myelin-Oligodendrocyte Glycoprotein)
SB  - IM
MH  - Animals
MH  - Arthritis, Rheumatoid/*genetics
MH  - Central Nervous System/immunology
MH  - Chemokines/genetics
MH  - Chemokines, CC/*genetics
MH  - Encephalomyelitis, Autoimmune, Experimental/*genetics/immunology
MH  - Genetic Linkage
MH  - Genotype
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Mice
MH  - Multiple Sclerosis/*genetics
MH  - Myelin Proteins
MH  - Myelin-Associated Glycoprotein/genetics/immunology
MH  - Myelin-Oligodendrocyte Glycoprotein
MH  - Rats
EDAT- 2009/10/30 06:00
MHDA- 2010/06/15 06:00
CRDT- 2009/10/30 06:00
PHST- 2009/10/30 06:00 [entrez]
PHST- 2009/10/30 06:00 [pubmed]
PHST- 2010/06/15 06:00 [medline]
AID - gene200982 [pii]
AID - 10.1038/gene.2009.82 [doi]
PST - ppublish
SO  - Genes Immun. 2010 Mar;11(2):142-54. doi: 10.1038/gene.2009.82. Epub 2009 Oct 29.