PMID- 19875998 OWN - NLM STAT- MEDLINE DCOM- 20100721 LR - 20211020 IS - 1930-739X (Electronic) IS - 1930-7381 (Print) IS - 1930-7381 (Linking) VI - 18 IP - 5 DP - 2010 May TI - Relationships of obesity and fat distribution with atherothrombotic risk factors: baseline results from the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial. PG - 1046-54 LID - 10.1038/oby.2009.339 [doi] AB - The impact of obesity on cardiovascular disease (CVD) outcomes in patients with type 2 diabetes mellitus (T2DM) and established coronary artery disease (CAD) is controversial; whether BMI and/or waist circumference correlate with atherothrombotic risk factors in such patients is uncertain. We sought to evaluate whether higher BMI or waist circumference are associated with specific risk factors among 2,273 Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) study participants with T2DM and documented CAD (baseline data, mean age 62 years, 66% non-Hispanic white, 71% men). Multiple linear regression models were constructed after adjusting for sex, age, race/ethnicity, US vs. non-US site, diabetes duration, exercise, smoking, alcohol, and relevant medication use. First-order partial correlations of BMI with risk factors after controlling for waist circumference and of waist circumference with risk factors after controlling for BMI were also evaluated. Ninety percent of the patients were overweight (BMI > or =25 kg/m(2)); 68% of men and 89% of women had high-risk waist circumference measures (> or =102 and > or =88 cm, respectively). BMI and waist circumference, in separate models, explained significant variation in metabolic (insulin, lipids, blood pressure (BP)) and inflammatory/procoagulation (C-reactive protein, PAI-1 activity and antigen, and fibrinogen) risk factors. In partial correlation analyses BMI was independently associated with BP and inflammatory/procoagulation factors, waist circumference with lipids, and both BMI and waist circumference with insulin. We conclude that, in cross-sectional analyses, both BMI and waist circumference, independently, are associated with increased atherothrombotic risk in centrally obese cohorts such as the BARI 2D patients with T2DM and CAD. FAU - Albu, Jeanine B AU - Albu JB AD - Department of Medicine and the New York Obesity Research Center, St Luke's Roosevelt Hospital Center, New York, NY, USA. jba1@columbia.edu FAU - Lu, Jiang AU - Lu J FAU - Mooradian, Arshag D AU - Mooradian AD FAU - Krone, Ronald J AU - Krone RJ FAU - Nesto, Richard W AU - Nesto RW FAU - Porter, Marty H AU - Porter MH FAU - Rana, Jamal S AU - Rana JS FAU - Rogers, William J AU - Rogers WJ FAU - Sobel, Burton E AU - Sobel BE FAU - Gottlieb, Sheldon H AU - Gottlieb SH CN - BARI 2D Study Group LA - eng GR - M01 RR000645/RR/NCRR NIH HHS/United States GR - R01 HL71306/HL/NHLBI NIH HHS/United States GR - HL061744/HL/NHLBI NIH HHS/United States GR - U01 HL061746/HL/NHLBI NIH HHS/United States GR - R01 HL071306/HL/NHLBI NIH HHS/United States GR - U01 HL061748/HL/NHLBI NIH HHS/United States GR - U01 HL061744/HL/NHLBI NIH HHS/United States GR - U01 HL063804/HL/NHLBI NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20091029 PL - United States TA - Obesity (Silver Spring) JT - Obesity (Silver Spring, Md.) JID - 101264860 SB - IM MH - Adult MH - Aged MH - *Body Fat Distribution MH - Body Mass Index MH - Cross-Sectional Studies MH - Diabetes Mellitus, Type 2/complications MH - Female MH - Humans MH - Life Style MH - Male MH - Middle Aged MH - Obesity/*complications MH - Regression Analysis MH - Risk MH - Risk Assessment MH - Risk Factors MH - Vascular Diseases/*complications MH - Waist Circumference PMC - PMC4430329 MID - NIHMS687205 COIS- DISCLOSURE The authors declared no conflict of interest. EDAT- 2009/10/31 06:00 MHDA- 2010/07/22 06:00 PMCR- 2015/05/13 CRDT- 2009/10/31 06:00 PHST- 2009/10/31 06:00 [entrez] PHST- 2009/10/31 06:00 [pubmed] PHST- 2010/07/22 06:00 [medline] PHST- 2015/05/13 00:00 [pmc-release] AID - oby2009339 [pii] AID - 10.1038/oby.2009.339 [doi] PST - ppublish SO - Obesity (Silver Spring). 2010 May;18(5):1046-54. doi: 10.1038/oby.2009.339. Epub 2009 Oct 29.