PMID- 19875999
OWN - NLM
STAT- MEDLINE
DCOM- 20100721
LR  - 20211020
IS  - 1930-739X (Electronic)
IS  - 1930-7381 (Print)
IS  - 1930-7381 (Linking)
VI  - 18
IP  - 5
DP  - 2010 May
TI  - Pericardial fat volume correlates with inflammatory markers: the Framingham Heart 
      Study.
PG  - 1039-45
LID - 10.1038/oby.2009.343 [doi]
AB  - The objective of this study was to determine whether systemic inflammatory and 
      oxidative stress marker concentrations correlate with pericardial and 
      intrathoracic fat volumes. Participants of the Framingham Offspring Study (n = 
      1,175, 53% women, mean age 59 +/- 9 years) had pericardial and intrathoracic fat 
      volumes assessed by multidetector computed tomography (MDCT) scans, and provided 
      fasting blood and urine samples to measure concentrations of 14 inflammatory 
      markers: C-reactive protein (CRP), interleukin-6, monocyte chemoattractant 
      protein-1 (MCP-1), CD40 ligand, fibrinogen, intracellular adhesion molecule-1, 
      lipoprotein-associated phospholipase A(2) activity and mass, myeloperoxidase, 
      osteoprotegerin, P-selectin, tumor necrosis factor-alpha, tumor necrosis factor 
      receptor-2, and urinary isoprostanes. Multivariable linear regression models were 
      used to determine the association of log-transformed inflammatory marker 
      concentrations with fat volumes, using fat volume as the dependent variable. Due 
      to smaller sample sizes, models were rerun after adding urinary isoprostanes (n = 
      961) and tumor necrosis factor-alpha (n = 813) to the marker panel. Upon backward 
      elimination, four of the biomarkers correlated positively with each fat depot: 
      CRP (P < 0.0001 for each fat depot), interleukin-6 (P < 0.05 for each fat depot), 
      MCP-1 (P < 0.01 for each fat depot), and urinary isoprostanes (P < 0.01 for 
      pericardial fat; P < 0.001 for intrathoracic fat). Even after adjusting for BMI, 
      waist circumference (WC), and abdominal visceral fat, CRP (P = 0.0001) and 
      urinary isoprostanes (P = 0.02) demonstrated significant positive associations 
      with intrathoracic fat, but not with pericardial fat. Multiple markers of 
      inflammation and oxidative stress correlated with pericardial and intrathoracic 
      fat volumes, extending the known association between regional adiposity and 
      inflammation and oxidative stress.
FAU - Tadros, Thomas M
AU  - Tadros TM
AD  - National Heart, Lung, and Blood Institute's Framingham Heart Study, Boston, 
      Massachusetts, USA.
FAU - Massaro, Joseph M
AU  - Massaro JM
FAU - Rosito, Guido A
AU  - Rosito GA
FAU - Hoffmann, Udo
AU  - Hoffmann U
FAU - Vasan, Ramachandran S
AU  - Vasan RS
FAU - Larson, Martin G
AU  - Larson MG
FAU - Keaney, John F Jr
AU  - Keaney JF Jr
FAU - Lipinska, Izabella
AU  - Lipinska I
FAU - Meigs, James B
AU  - Meigs JB
FAU - Kathiresan, Sekar
AU  - Kathiresan S
FAU - O'Donnell, Christopher J
AU  - O'Donnell CJ
FAU - Fox, Caroline S
AU  - Fox CS
FAU - Benjamin, Emelia J
AU  - Benjamin EJ
LA  - eng
GR  - N01-HC-25195/HC/NHLBI NIH HHS/United States
GR  - M01 RR001066-26/RR/NCRR NIH HHS/United States
GR  - R01 HL076784/HL/NHLBI NIH HHS/United States
GR  - K24 DK080140-03/DK/NIDDK NIH HHS/United States
GR  - 2K24HL04334/HL/NHLBI NIH HHS/United States
GR  - M01 RR001066/RR/NCRR NIH HHS/United States
GR  - K24 DK080140/DK/NIDDK NIH HHS/United States
GR  - N01HC25195/HL/NHLBI NIH HHS/United States
GR  - R01 AG028321-04/AG/NIA NIH HHS/United States
GR  - R01-AG028321/AG/NIA NIH HHS/United States
GR  - R01 HL064753-04/HL/NHLBI NIH HHS/United States
GR  - N01 HC025195/HC/NHLBI NIH HHS/United States
GR  - K24 HL004334/HL/NHLBI NIH HHS/United States
GR  - R01-HL076784/HL/NHLBI NIH HHS/United States
GR  - K24 HL004334-08/HL/NHLBI NIH HHS/United States
GR  - R01 HL076784-05/HL/NHLBI NIH HHS/United States
GR  - M01-RR-01066/RR/NCRR NIH HHS/United States
GR  - R01 AG028321/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20091029
PL  - United States
TA  - Obesity (Silver Spring)
JT  - Obesity (Silver Spring, Md.)
JID - 101264860
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adipose Tissue, White/diagnostic imaging/metabolism/*pathology
MH  - Adult
MH  - Aged
MH  - Biomarkers/metabolism
MH  - Body Mass Index
MH  - Female
MH  - Humans
MH  - Inflammation/diagnostic imaging/*metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Organ Size
MH  - Oxidative Stress
MH  - Patient Selection
MH  - Pericardium/diagnostic imaging/metabolism/*pathology
MH  - Radiography
MH  - Regression Analysis
MH  - Sex Factors
MH  - Waist Circumference
PMC - PMC3014610
MID - NIHMS208622
COIS- DISCLOSURE The authors declared no conflict of interest.
EDAT- 2009/10/31 06:00
MHDA- 2010/07/22 06:00
PMCR- 2011/05/01
CRDT- 2009/10/31 06:00
PHST- 2009/10/31 06:00 [entrez]
PHST- 2009/10/31 06:00 [pubmed]
PHST- 2010/07/22 06:00 [medline]
PHST- 2011/05/01 00:00 [pmc-release]
AID - oby2009343 [pii]
AID - 10.1038/oby.2009.343 [doi]
PST - ppublish
SO  - Obesity (Silver Spring). 2010 May;18(5):1039-45. doi: 10.1038/oby.2009.343. Epub 
      2009 Oct 29.