PMID- 1987792
OWN - NLM
STAT- MEDLINE
DCOM- 19910221
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 260
IP  - 1 Pt 1
DP  - 1991 Jan
TI  - Interaction of exercise and insulin action in humans.
PG  - E37-45
AB  - To assess the interaction of exercise and insulin action, healthy males were 
      studied with saline infusion (n = 5) or with a hyperinsulinemic euglycemic clamp 
      (0.5, 1.0, 2.0, or 15.0 mU.kg-1.min-1; n = 5 at each dose) during rest (40 min), 
      moderate-intensity cycle exercise (100 min), and recovery (100 min). Metabolism 
      was assessed using isotopic methods and indirect calorimetry. During rest, 
      exercise, and recovery with saline infusion, plasma glucose was unchanged, total 
      glucose utilization (Rd) was 2.4 +/- 0.4, 4.9 +/- 0.2, and 2.6 +/- 0.2 
      mg.kg-1.min-1, and carbohydrate (CHO) oxidation (OX) was 1.4 +/- 0.3, 10.6 +/- 
      1.1, and 0.5 +/- 0.2 mg.kg-1.min-1. The glucose infusion, insulin-dependent Rd, 
      and CHO OX increased synergistically when exercise and insulin clamps were 
      combined. Exercise decreased (P less than 0.05) the half-maximal doses (ED50) and 
      increased the maximal responses (Vmax) for insulin-dependent Rd and CHO OX. 
      Estimates of insulin-independent Rd were 1.3 +/- 0.7, 4.1 +/- 1.3, and 1.9 +/- 
      0.7 mg.kg-1.min-1 and insulin-independent CHO OX were 1.2 +/- 0.9, 10.4 +/- 1.3, 
      and 0.6 +/- 0.3 mg.kg-1.min-1 during rest, exercise, and recovery. Estimates 
      during exercise were greater than those at rest (P less than 0.05). The total 
      suppression of free fatty acids (FFA) and fat OX by insulin were elevated by 
      exercise (P less than 0.05). In summary, exercise and insulin interact 
      synergistically in stimulating Rd and CHO OX.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Wasserman, D H
AU  - Wasserman DH
AD  - Department of Molecular Physiology and Biophysics, Vanderbilt University School 
      of Medicine, Nashville, Tennessee 37232.
FAU - Geer, R J
AU  - Geer RJ
FAU - Rice, D E
AU  - Rice DE
FAU - Bracy, D
AU  - Bracy D
FAU - Flakoll, P J
AU  - Flakoll PJ
FAU - Brown, L L
AU  - Brown LL
FAU - Hill, J O
AU  - Hill JO
FAU - Abumrad, N N
AU  - Abumrad NN
LA  - eng
GR  - DK-26657/DK/NIDDK NIH HHS/United States
GR  - DK-42488/DK/NIDDK NIH HHS/United States
GR  - SP60-AM-20593-08/SP/CSAP SAMHSA HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (Amino Acids)
RN  - 0 (Blood Glucose)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (Insulin)
RN  - 0 (Lactates)
RN  - IY9XDZ35W2 (Glucose)
RN  - PDC6A3C0OX (Glycerol)
RN  - X4W3ENH1CV (Norepinephrine)
RN  - YKH834O4BH (Epinephrine)
SB  - IM
MH  - Adult
MH  - Amino Acids/blood
MH  - Blood Glucose/*metabolism
MH  - *Carbohydrate Metabolism
MH  - Epinephrine/*blood
MH  - *Exercise
MH  - Fatty Acids, Nonesterified/blood
MH  - Glucose/metabolism
MH  - Glucose Clamp Technique
MH  - Glycerol/blood
MH  - Humans
MH  - Insulin/blood/*pharmacology
MH  - Insulin Infusion Systems
MH  - Lactates/blood
MH  - Male
MH  - Norepinephrine/*blood
MH  - *Physical Exertion
MH  - Reference Values
EDAT- 1991/01/01 00:00
MHDA- 1991/01/01 00:01
CRDT- 1991/01/01 00:00
PHST- 1991/01/01 00:00 [pubmed]
PHST- 1991/01/01 00:01 [medline]
PHST- 1991/01/01 00:00 [entrez]
AID - 10.1152/ajpendo.1991.260.1.E37 [doi]
PST - ppublish
SO  - Am J Physiol. 1991 Jan;260(1 Pt 1):E37-45. doi: 10.1152/ajpendo.1991.260.1.E37.