PMID- 19878416
OWN - NLM
STAT- MEDLINE
DCOM- 20100126
LR  - 20190108
IS  - 1556-4029 (Electronic)
IS  - 0022-1198 (Linking)
VI  - 54
IP  - 6
DP  - 2009 Nov
TI  - Morbidity involving the hallucinogenic designer amines MDA and 2C-I.
PG  - 1485-7
LID - 10.1111/j.1556-4029.2009.01199.x [doi]
AB  - A case is presented of a 39-year-old woman who suffered severe debilitation 
      because of a hemorrhagic stroke in the context of substance abuse. The patient 
      presented to the emergency room with rapidly diminishing mental status, 
      hypertension, and vasoconstriction; her friends provided a history of ingestion 
      of cocaine, 3,4-methylenedioxymethamphetamine (MDMA), and 2C-I, a novel designer 
      amine. A multi-targeted LC-MS/MS method for sympathomimetic amines and related 
      drugs in urine detected and quantified 2C-I and MDA, while ruling out MDMA. The 
      cause of the stroke was determined to be an underlying cerebrovascular 
      abnormality called Moyamoya, secondary to substance abuse. In clinical 
      laboratories, gas chromatography-mass spectrometry or liquid 
      chromatography-tandem mass spectrometry (LC-MS/MS) confirmation of a positive 
      amphetamine immunoassay is usually directed only towards amphetamine, 
      methamphetamine, MDMA and MDA. This report demonstrates the utility of testing 
      for a wider menu of compounds using LC-MS/MS in order to better characterize the 
      prevalence and toxicities of novel amines such as 2C-I.
FAU - Drees, Julia C
AU  - Drees JC
AD  - Department of Laboratory Medicine, University of California-San Francisco, San 
      Francisco, CA, USA.
FAU - Stone, Judy A
AU  - Stone JA
FAU - Wu, Alan H B
AU  - Wu AH
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Forensic Sci
JT  - Journal of forensic sciences
JID - 0375370
RN  - 0 (Designer Drugs)
RN  - 0 (Dimethoxyphenylethylamine)
RN  - 0 (Hallucinogens)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - S35362848V (4-iodo-2,5-dimethoxy-beta-phenethylamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/*adverse effects/analysis
MH  - Adult
MH  - Chromatography, Gas
MH  - Designer Drugs/*adverse effects/analysis
MH  - Dimethoxyphenylethylamine/adverse effects/*analogs & derivatives/analysis
MH  - Female
MH  - Forensic Toxicology
MH  - Gas Chromatography-Mass Spectrometry
MH  - Hallucinogens/*adverse effects/analysis
MH  - Humans
MH  - Intracranial Hemorrhages/*etiology
MH  - Moyamoya Disease/complications/diagnosis
MH  - Quadriplegia/etiology
MH  - Stroke/*etiology
MH  - Substance Abuse Detection/methods
MH  - Substance-Related Disorders/complications
EDAT- 2009/11/03 06:00
MHDA- 2010/01/27 06:00
CRDT- 2009/11/03 06:00
PHST- 2009/11/03 06:00 [entrez]
PHST- 2009/11/03 06:00 [pubmed]
PHST- 2010/01/27 06:00 [medline]
AID - JFO1199 [pii]
AID - 10.1111/j.1556-4029.2009.01199.x [doi]
PST - ppublish
SO  - J Forensic Sci. 2009 Nov;54(6):1485-7. doi: 10.1111/j.1556-4029.2009.01199.x.