PMID- 19878513
OWN - NLM
STAT- MEDLINE
DCOM- 20110602
LR  - 20131121
IS  - 1399-0012 (Electronic)
IS  - 0902-0063 (Linking)
VI  - 25
IP  - 1
DP  - 2011 Jan-Feb
TI  - Homocysteine and P wave dispersion in patients with heart transplantation.
PG  - 119-25
LID - 10.1111/j.1399-0012.2009.01126.x [doi]
AB  - BACKGROUND: Hyperhomocysteinemia (HHcy), a putative independent risk factor for 
      the development of atherotrombosis in the general population, represents a very 
      common finding in orthotopic heart transplantation (OHT) patients. Starting from 
      previous studies suggesting a pro-arrhythmogenic activity of homocysteine (Hcy), 
      we evaluated the possible correlation among Hcy plasma levels and P wave 
      dispersion (PWD), corrected QT interval (QTc), and QTc dispersion (QTcD) as 
      parameters of electric instability of the myocardium in patients undergone OHT 
      whose hearts are therefore completely denervated, thus unresponsive to autonomic 
      influences. METHODS AND RESULTS: Homocysteine plasma levels, PWD, QTc, QTcD, and 
      QTc dynamics were measured in 32 patients, who underwent OHT, and in 20 control 
      subjects. In OHT patients, PWD (39.5 +/- 11 vs. 34 +/- 6 ms, p = 0.04) and QTc 
      interval (438 +/- 20 vs. 410 +/- 10 ms, p < 0.001) were significantly higher in 
      comparison with control subjects. Moreover, OHT subjects with HHcy had higher PWD 
      values than those with normal Hcy plasma levels (44.1 +/- 10.7 vs. 33.9 +/- 8.8 ms, p 
      = 0.007), but no difference was found between this latter OHT group and controls. 
      Accordingly, in OHT patients, plasma Hcy level correlated significantly with PWD 
      (Spearman r = 0.70; p < 0.0001), whereas no correlation was found with QTc, QTcD, 
      and QTc circadian dynamics. CONCLUSION: HHcy seems associated with an alteration 
      in the electrical atrial conduction, possibly contributing, at least in part, to 
      the increased risk of cardiac arrhythmias in the denervated hearts of OHT 
      patients.
CI  - (c) 2009 John Wiley & Sons A/S.
FAU - Acampa, Maurizio
AU  - Acampa M
AD  - Division of Internal Medicine, Department of Clinical Medicine and Immunological 
      Sciences, University of Siena, Siena, Italy. M.Acampa@ao-siena.toscana.it
FAU - Lazzerini, Pietro Enea
AU  - Lazzerini PE
FAU - Guideri, Francesca
AU  - Guideri F
FAU - Rechichi, Serena
AU  - Rechichi S
FAU - Capecchi, Pier Leopoldo
AU  - Capecchi PL
FAU - Maccherini, Massimo
AU  - Maccherini M
FAU - Laghi-Pasini, Franco
AU  - Laghi-Pasini F
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Denmark
TA  - Clin Transplant
JT  - Clinical transplantation
JID - 8710240
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Arrhythmias, Cardiac/*diagnosis/etiology
MH  - Case-Control Studies
MH  - *Electrocardiography
MH  - Female
MH  - Follow-Up Studies
MH  - Heart/*physiopathology
MH  - *Heart Transplantation
MH  - Homocysteine/*blood
MH  - Humans
MH  - Hyperhomocysteinemia/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Survival Rate
MH  - Treatment Outcome
EDAT- 2009/11/03 06:00
MHDA- 2011/06/03 06:00
CRDT- 2009/11/03 06:00
PHST- 2009/11/03 06:00 [entrez]
PHST- 2009/11/03 06:00 [pubmed]
PHST- 2011/06/03 06:00 [medline]
AID - CTR1126 [pii]
AID - 10.1111/j.1399-0012.2009.01126.x [doi]
PST - ppublish
SO  - Clin Transplant. 2011 Jan-Feb;25(1):119-25. doi: 
      10.1111/j.1399-0012.2009.01126.x.