PMID- 19878610
OWN - NLM
STAT- MEDLINE
DCOM- 20100401
LR  - 20131121
IS  - 1475-2662 (Electronic)
IS  - 0007-1145 (Linking)
VI  - 103
IP  - 6
DP  - 2010 Mar
TI  - Curcumin suppresses p38 mitogen-activated protein kinase activation, reduces 
      IL-1beta and matrix metalloproteinase-3 and enhances IL-10 in the mucosa of 
      children and adults with inflammatory bowel disease.
PG  - 824-32
LID - 10.1017/S0007114509992510 [doi]
AB  - Inflammatory bowel disease (IBD) is a major source of morbidity in children and 
      adults. Its incidence is rising, particularly in young people. IBD carries a 
      lifelong risk of cancer, which is proportional to disease duration. Drug and 
      surgical treatments rarely offer cure and often carry a high side effect burden. 
      Dietary therapy is highly effective in Crohn's disease. For these reasons, there 
      is much interest in developing novel dietary treatments in IBD. Curcumin, a 
      component of the spice turmeric, and an anti-inflammatory and anti-cancer agent, 
      shows preclinical and clinical potential in IBD. Its mechanisms of action are 
      unknown. Our aim was to assess the effect of curcumin on key disease mediators 
      p38 mitogen-activated protein kinase (MAPK), IL-1beta, IL-10 and matrix 
      metalloproteinase-3 (MMP-3) in the gut of children and adults with IBD. Colonic 
      mucosal biopsies and colonic myofibroblasts (CMF) from children and adults with 
      active IBD were cultured ex vivo with curcumin. p38 MAPK, NF-kappaB and MMP-3 
      were measured by immunoblotting. IL-1beta and IL-10 were measured by ELISA. We 
      show reduced p38 MAPK activation in curcumin-treated mucosal biopsies, enhanced 
      IL-10 and reduced IL-1beta. We demonstrate dose-dependent suppression of MMP-3 in 
      CMF with curcumin. We conclude that curcumin, a naturally occurring food 
      substance with no known human toxicity, holds promise as a novel therapy in IBD.
FAU - Epstein, Jenny
AU  - Epstein J
AD  - Centre for Digestive Diseases, Institute of Cell and Molecular Science, Barts and 
      the London School of Medicine, Queen Mary, University of London, London E1 2AT, 
      UK. j.epstein@qmul.ac.uk
FAU - Docena, Guillermo
AU  - Docena G
FAU - MacDonald, Thomas T
AU  - MacDonald TT
FAU - Sanderson, Ian R
AU  - Sanderson IR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091102
PL  - England
TA  - Br J Nutr
JT  - The British journal of nutrition
JID - 0372547
RN  - 0 (Interleukin-1beta)
RN  - 130068-27-8 (Interleukin-10)
RN  - EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Acetylation/drug effects
MH  - Adolescent
MH  - Biopsy
MH  - Child
MH  - Colon
MH  - Curcumin/*pharmacology
MH  - Enzyme Activation/drug effects
MH  - Fibroblasts
MH  - Humans
MH  - Inflammatory Bowel Diseases/*drug therapy/metabolism
MH  - Interleukin-10/*analysis
MH  - Interleukin-1beta/*analysis
MH  - Intestinal Mucosa/chemistry/drug effects/enzymology
MH  - Matrix Metalloproteinase 3/*analysis
MH  - Phosphorylation/drug effects
MH  - p38 Mitogen-Activated Protein Kinases/*metabolism
EDAT- 2009/11/03 06:00
MHDA- 2010/04/02 06:00
CRDT- 2009/11/03 06:00
PHST- 2009/11/03 06:00 [entrez]
PHST- 2009/11/03 06:00 [pubmed]
PHST- 2010/04/02 06:00 [medline]
AID - S0007114509992510 [pii]
AID - 10.1017/S0007114509992510 [doi]
PST - ppublish
SO  - Br J Nutr. 2010 Mar;103(6):824-32. doi: 10.1017/S0007114509992510. Epub 2009 Nov 
      2.