PMID- 19879368
OWN - NLM
STAT- MEDLINE
DCOM- 20100621
LR  - 20131121
IS  - 1095-9564 (Electronic)
IS  - 1074-7427 (Linking)
VI  - 93
IP  - 2
DP  - 2010 Feb
TI  - Effects of anesthetic agents on socially transmitted olfactory memories in mice.
PG  - 268-74
LID - 10.1016/j.nlm.2009.10.007 [doi]
AB  - Mice can learn a food preference from odor cues transmitted on the breath of a 
      conspecific, even if the "demonstrator" is anesthetized. To our knowledge there 
      are no studies examining the effect of anesthetizing the "observer" on 
      development of memory for socially transmitted food preferences (STFP). In 
      Experiment 1 we found that 2-4 month-old F2 C57Bl/6x129sv male and female mice 
      demonstrated a STFP after a 5min exposure to an anesthetized demonstrator mouse 
      when tested 24h later. In Experiment 2, observer mice anesthetized with Sagatal 
      (60 mg/kg) prior to the "social interaction" preferentially avoided the cued food 
      when tested 24h later. This aversion was not due to any overt aversive effects of 
      this dose of Sagatal because mice that ate the food and were then anesthetized, 
      or could only smell the food for 5 min while anesthetized, showed no preference 
      or aversion. In a third experiment we found that the Sagatal-induced aversion was 
      not a general property of anesthesia because there were varied results produced 
      by observer mice treated with anesthetic drugs with different mechanisms of 
      action. Vetalar (200mg/kg) and Rompun (10 mg/kg) treated animals ate similar 
      amounts of cued and non-cued food at test, indicating an absence of learning. 
      Hypnorm (0.5 ml/kg) treated animals showed a preference for the cued food whereas 
      those treated with Hypnovel (2.5 ml/kg) showed an aversion to the cued food. 
      These results show that the food aversion observed with Sagatal is not a general 
      property of anesthetic agents, but appears to be restricted to those acting 
      primarily on the GABAergic system. Thus, we have shown that under certain 
      conditions it is possible for an anesthetized observer mouse to learn a 
      preference or aversion of a socially-linked olfactory cue.
CI  - Crown Copyright 2009. Published by Elsevier Inc. All rights reserved.
FAU - Burne, T H J
AU  - Burne TH
AD  - Cognitive and Systems Neuroscience, Babraham Institute, Babraham, Cambridge CB22 
      3AQ, UK. t.burne@uq.edu.au
FAU - Johnston, A N B
AU  - Johnston AN
FAU - Wilkinson, L S
AU  - Wilkinson LS
FAU - Kendrick, K M
AU  - Kendrick KM
LA  - eng
GR  - Biotechnology and Biological Sciences Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091029
PL  - United States
TA  - Neurobiol Learn Mem
JT  - Neurobiology of learning and memory
JID - 9508166
RN  - 0 (Anesthetics)
RN  - 0 (Butyrophenones)
RN  - 0 (Central Nervous System Agents)
RN  - 0 (Drug Combinations)
RN  - 2KFG9TP5V8 (Xylazine)
RN  - 52869-98-4 (Hypnorm)
RN  - I4744080IR (Pentobarbital)
RN  - UF599785JZ (Fentanyl)
SB  - IM
MH  - Anesthetics/*pharmacology
MH  - Animals
MH  - Butyrophenones/pharmacology
MH  - Central Nervous System Agents/*pharmacology
MH  - Cues
MH  - Drug Combinations
MH  - Female
MH  - Fentanyl/pharmacology
MH  - Food Preferences/*drug effects
MH  - Male
MH  - Memory/*drug effects
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neuropsychological Tests
MH  - Olfactory Perception/*drug effects
MH  - Pentobarbital/pharmacology
MH  - *Social Behavior
MH  - Time Factors
MH  - Xylazine/pharmacology
EDAT- 2009/11/03 06:00
MHDA- 2010/06/22 06:00
CRDT- 2009/11/03 06:00
PHST- 2009/04/02 00:00 [received]
PHST- 2009/10/23 00:00 [revised]
PHST- 2009/10/27 00:00 [accepted]
PHST- 2009/11/03 06:00 [entrez]
PHST- 2009/11/03 06:00 [pubmed]
PHST- 2010/06/22 06:00 [medline]
AID - S1074-7427(09)00210-X [pii]
AID - 10.1016/j.nlm.2009.10.007 [doi]
PST - ppublish
SO  - Neurobiol Learn Mem. 2010 Feb;93(2):268-74. doi: 10.1016/j.nlm.2009.10.007. Epub 
      2009 Oct 29.