PMID- 19879463
OWN - NLM
STAT- MEDLINE
DCOM- 20100629
LR  - 20151119
IS  - 1532-8414 (Electronic)
IS  - 1071-9164 (Linking)
VI  - 15
IP  - 9
DP  - 2009 Nov
TI  - Antibodies to oxidized LDL as predictors of morbidity and mortality in patients 
      with chronic heart failure.
PG  - 770-4
LID - 10.1016/j.cardfail.2009.05.009 [doi]
AB  - BACKGROUND: Oxidative stress appears to play a significant role in the 
      pathogenesis of heart failure (HF). Antibodies to oxidized low-density 
      lipoprotein (Ox LDL Abs) reflect an immune response to LDL over a prolonged 
      period and may thus represent oxidative stress over an extended time. Ox LDL Abs 
      have been shown to correlate with clinical control in HF patients. We evaluated 
      the predictive power of Ox LDL Abs on the outcome in patients with HF. METHODS 
      AND RESULTS: Baseline levels of Ox LDL Abs were determined by enzyme-linked 
      immunosorbent assay in 284 consecutive outpatients with severe chronic HF who 
      were being treated in the cardiology services of our medical center. Their mean 
      New York Heart Association (NYHA) Class was 2.8. The mean follow-up for the group 
      was 3.7 years, during which 107 (37%) died. The mean time from symptom onset to 
      first hospital admission from HF was 25.8 months. Ox LDL Abs were found to 
      predict morbidity and mortality as evaluated by a Cox multivariate regression 
      analysis with a hazard ration of 1.013 (P < .013), whereas N-terminal pro-B-type 
      natriuretic peptide (NT pro-BNP) levels achieved a HR of 1.028 (P < .099). 
      CONCLUSIONS: Ox LDL Abs level maybe a useful parameter for monitoring and 
      planning better management of patients with HF. It was superior to pro-BNP as a 
      predictor of clinical course as expressed by time to hospitalization.
FAU - Charach, Gideon
AU  - Charach G
AD  - Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. 
      drcharach@012.net.il
FAU - George, Jacob
AU  - George J
FAU - Afek, Arnon
AU  - Afek A
FAU - Wexler, Dov
AU  - Wexler D
FAU - Sheps, David
AU  - Sheps D
FAU - Keren, Gad
AU  - Keren G
FAU - Rubinstein, Ardon
AU  - Rubinstein A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20090703
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
RN  - 0 (Antibodies)
RN  - 0 (Biomarkers)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Lipoproteins, LDL)
RN  - 0 (Peptide Fragments)
RN  - 0 (oxidized low density lipoprotein)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antibodies/*blood
MH  - Biomarkers/blood
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/blood/*immunology/*mortality
MH  - Hospitalization/trends
MH  - Humans
MH  - Immunoglobulin G/biosynthesis/blood
MH  - Lipoproteins, LDL/blood/*immunology
MH  - Male
MH  - Middle Aged
MH  - Morbidity/trends
MH  - Natriuretic Peptide, Brain/blood
MH  - Peptide Fragments/blood
MH  - Predictive Value of Tests
MH  - Prospective Studies
EDAT- 2009/11/03 06:00
MHDA- 2010/06/30 06:00
CRDT- 2009/11/03 06:00
PHST- 2008/11/22 00:00 [received]
PHST- 2009/05/04 00:00 [revised]
PHST- 2009/05/07 00:00 [accepted]
PHST- 2009/11/03 06:00 [entrez]
PHST- 2009/11/03 06:00 [pubmed]
PHST- 2010/06/30 06:00 [medline]
AID - S1071-9164(09)00171-7 [pii]
AID - 10.1016/j.cardfail.2009.05.009 [doi]
PST - ppublish
SO  - J Card Fail. 2009 Nov;15(9):770-4. doi: 10.1016/j.cardfail.2009.05.009. Epub 2009 
      Jul 3.