PMID- 19879790
OWN - NLM
STAT- MEDLINE
DCOM- 20100222
LR  - 20220408
IS  - 1878-1780 (Electronic)
IS  - 1262-3636 (Linking)
VI  - 35
IP  - 6
DP  - 2009 Dec
TI  - Early-stage atherosclerosis in newly diagnosed, untreated type 2 diabetes 
      mellitus and impaired glucose tolerance.
PG  - 458-62
LID - 10.1016/j.diabet.2009.05.005 [doi]
AB  - AIM: The aim of this study was to investigate early-stage atherosclerosis in 
      newly diagnosed, untreated type 2 diabetes mellitus (T2DM) and impaired glucose 
      tolerance (IGT). METHODS: The study subjects underwent an oral glucose tolerance 
      test (OGTT) and were then divided into three groups, according to plasma glucose 
      level: those in the normal glucose tolerance (NGT) group had fasting plasma 
      glucose (FPG)<6.1mmol/L and 2h postload glucose (2hPPG)<7.8mmol/L; those in the 
      IGT group had FPG<6.1mmol/L and 2hPPG>or=7.8mmol/L; and those in the T2DM group 
      had FPG>or=7.0mmol/L or 2hPPG>or=11.1mmol/L. Haemodynamic variables and 
      brachial-ankle pulse-wave velocities (baPWV) in the three groups were compared. 
      RESULTS: The baPWV value increased with increases in plasma glucose, and was 
      significantly and positively correlated to age, FPG, 2hPPG, systolic blood 
      pressure (SBP), diastolic blood pressure (DBP), waist circumference and 
      waist-to-hip ratio. Significant differences were found between the baPWV values 
      in the NGT and IGT groups (1602+/-347 vs 1707+/-351cm/s, respectively; P=0.005), 
      and between the NGT and DM groups (1602+/-347 vs 1762+/-381, respectively; 
      P<0.001). The results of multiple regression analyses showed that 2hPPG was 
      closely related to baPWV as well as to SBP and DBP. CONCLUSION: Early-stage 
      atherosclerosis is present in newly diagnosed, untreated T2DM and IGT patients, 
      and it may be that its early assessment, along with good control of hypertension 
      and hyperglycaemia, will help to delay its progression.
FAU - Gong, W
AU  - Gong W
AD  - Department of Endocrinology and Metabolism, HuaShan Hospital, Shanghai, China.
FAU - Lu, B
AU  - Lu B
FAU - Yang, Z
AU  - Yang Z
FAU - Ye, W
AU  - Ye W
FAU - Du, Y
AU  - Du Y
FAU - Wang, M
AU  - Wang M
FAU - Li, Q
AU  - Li Q
FAU - Zhang, W
AU  - Zhang W
FAU - Pan, Y
AU  - Pan Y
FAU - Feng, X
AU  - Feng X
FAU - Zhou, W
AU  - Zhou W
FAU - Zhang, Y
AU  - Zhang Y
FAU - Yang, Z
AU  - Yang Z
FAU - Yang, Y
AU  - Yang Y
FAU - Zhu, X
AU  - Zhu X
FAU - Hu, R
AU  - Hu R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - France
TA  - Diabetes Metab
JT  - Diabetes & metabolism
JID - 9607599
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Aged
MH  - Analysis of Variance
MH  - Atherosclerosis/*complications/diagnosis
MH  - Body Mass Index
MH  - Brachial Artery/physiopathology
MH  - Diabetes Mellitus, Type 2/*complications/diagnosis
MH  - Female
MH  - Glucose
MH  - Glucose Intolerance/*complications/diagnosis
MH  - Glucose Tolerance Test
MH  - Hemodynamics/*physiology
MH  - Humans
MH  - Male
MH  - Metabolic Syndrome/diagnosis
MH  - Middle Aged
MH  - Regression Analysis
MH  - Waist-Hip Ratio
EDAT- 2009/11/03 06:00
MHDA- 2010/02/23 06:00
CRDT- 2009/11/03 06:00
PHST- 2009/02/10 00:00 [received]
PHST- 2009/05/18 00:00 [revised]
PHST- 2009/05/18 00:00 [accepted]
PHST- 2009/11/03 06:00 [entrez]
PHST- 2009/11/03 06:00 [pubmed]
PHST- 2010/02/23 06:00 [medline]
AID - S1262-3636(09)00174-8 [pii]
AID - 10.1016/j.diabet.2009.05.005 [doi]
PST - ppublish
SO  - Diabetes Metab. 2009 Dec;35(6):458-62. doi: 10.1016/j.diabet.2009.05.005.