PMID- 19879813
OWN - NLM
STAT- MEDLINE
DCOM- 20100630
LR  - 20181201
IS  - 1873-1449 (Electronic)
IS  - 1538-4721 (Linking)
VI  - 9
IP  - 2
DP  - 2010 Apr-Jun
TI  - Values of biologically equivalent doses in healthy tissues: comparison of PDR and 
      HDR brachytherapy techniques.
PG  - 165-70
LID - 10.1016/j.brachy.2009.08.007 [doi]
AB  - PURPOSE: The aim of this work was to compare the values of doses measured in 
      healthy tissues in chosen pulsed-dose-rate (PDR) brachytherapy (PDRBT) and 
      high-dose-rate (HDR) brachytherapy (HDRBT) fractionation schemas. METHODS AND 
      MATERIALS: Fifty-one patients treated with PDRBT were qualified for calculations. 
      This group included patients with head and neck cancer, brain tumor, breast 
      cancer, sarcoma, penile cancer, and rectal cancer. The doses were calculated in 
      chosen points in surrounded organs at risk (OaR). The biologically equivalent 
      dose (BED) formula was used to compare doses in PDRBT and HDRBT. RESULTS: One 
      ascertained that in biologically equivalent (to PDR) HDRBT, the increase of 
      fractional dose from 4 to 10 Gy caused the necessity to decrease the total dose 
      in treatment target (p<0.001). The use of HDR instead of PDR essentially caused 
      lower physical and biologic doses in examined OaR. In many examined critical 
      points in OaR where BED in the treatment area was the same, one ascertained the 
      decrease of total physical HDR dose according to the growth of the fractional 
      dose. Similar dependences were observed for BED. CONCLUSIONS: The use of 
      biologically equivalent HDRBT instead of PDRBT caused the decrease of physical 
      doses in the treatment target and the decrease of physical doses and BEDs in OaR. 
      Prolongation of intervals between pulses in PDRBT was connected with lower values 
      of BED doses in healthy tissues.
CI  - (c) 2010 American Brachytherapy Society. Published by Elsevier Inc. All rights 
      reserved.
FAU - Skowronek, Janusz
AU  - Skowronek J
AD  - Brachytherapy Department, Greater Poland Cancer Center, Poznan, Poland. 
      janusz.skowronek@wco.pl
FAU - Malicki, Julian
AU  - Malicki J
FAU - Piotrowski, Tomasz
AU  - Piotrowski T
LA  - eng
PT  - Comparative Study
PT  - Controlled Clinical Trial
PT  - Journal Article
DEP - 20091030
PL  - United States
TA  - Brachytherapy
JT  - Brachytherapy
JID - 101137600
SB  - IM
MH  - Adult
MH  - Brachytherapy/*methods
MH  - *Dose Fractionation, Radiation
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/*radiotherapy
MH  - *Radiotherapy Dosage
MH  - *Relative Biological Effectiveness
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2009/11/03 06:00
MHDA- 2010/07/01 06:00
CRDT- 2009/11/03 06:00
PHST- 2008/11/20 00:00 [received]
PHST- 2009/08/10 00:00 [revised]
PHST- 2009/08/18 00:00 [accepted]
PHST- 2009/11/03 06:00 [entrez]
PHST- 2009/11/03 06:00 [pubmed]
PHST- 2010/07/01 06:00 [medline]
AID - S1538-4721(09)00291-8 [pii]
AID - 10.1016/j.brachy.2009.08.007 [doi]
PST - ppublish
SO  - Brachytherapy. 2010 Apr-Jun;9(2):165-70. doi: 10.1016/j.brachy.2009.08.007. Epub 
      2009 Oct 30.