PMID- 19881965
OWN - NLM
STAT- MEDLINE
DCOM- 20100201
LR  - 20211020
IS  - 1976-2437 (Electronic)
IS  - 0513-5796 (Print)
IS  - 0513-5796 (Linking)
VI  - 50
IP  - 5
DP  - 2009 Oct 31
TI  - The clinical feature of Behcet's disease in Northeastern China.
PG  - 630-6
LID - 10.3349/ymj.2009.50.5.630 [doi]
AB  - PURPOSE: Behcet's disease (BD) is a chronic, relapsing, multi-system vasculitis 
      of unknown aetiology with complicated and diversified clinical features 
      predominantly involving oral and genital ulcers, and ocular and cutaneous 
      lesions. The clinical features of this disease have been described to be 
      different according to geographical areas and gender. We investigated the 
      specific clinical features of BD patients in Northeastern China. MATERIALS AND 
      METHODS: 116 patients involved in this study fulfilled the classification 
      criteria of the International Study Group for BD. The clinical manifestations and 
      results of laboratory tests of BD were recorded in each patient. RESULTS: The 
      onset was typically between 20-39 years with a slight female predominance. Oral 
      ulcers were the most common manifestation, followed by skin lesions, positive 
      pathergy reaction/genital ulcers, and ocular lesions. Vascular lesion and 
      epididymitis were rare in patients with BD. The frequency of erythema 
      nodosum-like lesion and articular involvement were significantly higher in 
      females, while gastrointestinal involvement was significantly higher in males. 
      The results of laboratory tests showed that the human leukocyte antigen 
      (HLA)-B*51 alleles were positive in 30.9% of patients and the immunological 
      abnormities were present in some patients. CONCLUSION: The clinical features of 
      BD showed geographical and gender difference. Genetic and immune factors might 
      participate in aetiopathogenesis of BD.
FAU - Shang, Yingbin
AU  - Shang Y
AD  - Department of Dermatology, No.1 Hospital of China Medical University, Shenyang, 
      China. shangyingbin@126.com
FAU - Han, Shixin
AU  - Han S
FAU - Li, Jiuhong
AU  - Li J
FAU - Ren, Qiushi
AU  - Ren Q
FAU - Song, Fangji
AU  - Song F
FAU - Chen, Hongduo
AU  - Chen H
LA  - eng
PT  - Journal Article
DEP - 20091020
PL  - Korea (South)
TA  - Yonsei Med J
JT  - Yonsei medical journal
JID - 0414003
SB  - IM
MH  - Behcet Syndrome/*diagnosis/epidemiology/pathology
MH  - China
MH  - Female
MH  - Geography
MH  - Humans
MH  - Male
PMC - PMC2768236
OTO - NOTNLM
OT  - Behcet's disease
OT  - autoimmune disease
OT  - clinical feature
COIS- The authors have no financial conflicts of interest.
EDAT- 2009/11/03 06:00
MHDA- 2010/02/02 06:00
PMCR- 2009/10/31
CRDT- 2009/11/03 06:00
PHST- 2008/09/11 00:00 [received]
PHST- 2008/12/17 00:00 [revised]
PHST- 2009/01/06 00:00 [accepted]
PHST- 2009/11/03 06:00 [entrez]
PHST- 2009/11/03 06:00 [pubmed]
PHST- 2010/02/02 06:00 [medline]
PHST- 2009/10/31 00:00 [pmc-release]
AID - 10.3349/ymj.2009.50.5.630 [doi]
PST - ppublish
SO  - Yonsei Med J. 2009 Oct 31;50(5):630-6. doi: 10.3349/ymj.2009.50.5.630. Epub 2009 
      Oct 20.