PMID- 19883218
OWN - NLM
STAT- MEDLINE
DCOM- 20100506
LR  - 20121115
IS  - 1556-9535 (Electronic)
IS  - 1556-9527 (Linking)
VI  - 29
IP  - 1
DP  - 2010 Mar
TI  - Methyldibromoglutaronitrile: skin sensitization and quantitative risk assessment.
PG  - 4-9
LID - 10.3109/15569520903351151 [doi]
AB  - Preservatives can be a frequent cause of allergic contact dermatitis (ACD). A 
      quantitative risk assessment (QRA) method for identifying safe exposure levels 
      has been suggested as a more effective tool for this purpose. This work assesses 
      the validity of QRA by its retrospective application to the sensitizing 
      preservative methyldibromoglutaronitrile (MDGN), which has recently been 
      associated with unacceptable exposure levels in consumer products. Using a 
      recently published QRA analysis of 4 preservatives in 5 consumer product types, 
      the accuracy of the predictions for MDGN was assessed in light of what is known 
      clinically about the nature and incidence of ACD to this material. Based on a 
      local lymph node assay (LLNA) EC3 value (concentration of test chemical required 
      to provoke a 3-fold increase in lymph node cell proliferation) of 0.9% in a 
      weight-of-evidence approach to the identification of thresholds for the induction 
      of skin sensitization, it can be determined that the acceptable levels of 
      exposure to MDGN in a range of products range from as little as 25 ppm to in 
      excess of 10,000 ppm. Thus, proactive use of QRA, used conservatively and in 
      combination with expert judgment, would have limited the problem of ACD to this 
      new preservative that is known to have caused problems on the consumer market.
FAU - Basketter, David A
AU  - Basketter DA
AD  - DABMEB Consultancy Ltd., Sharnbrook, Bedfordshire, UK. 
      david.basketter@ukonline.co.uk
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Cutan Ocul Toxicol
JT  - Cutaneous and ocular toxicology
JID - 101266892
RN  - 0 (Allergens)
RN  - 0 (Cosmetics)
RN  - 0 (Nitriles)
RN  - 0 (Preservatives, Pharmaceutical)
RN  - YX089CPS05 (1,2-dibromo-2,4-dicyanobutane)
SB  - IM
MH  - Allergens/*toxicity
MH  - Animals
MH  - Consumer Product Safety
MH  - Cosmetics/*toxicity
MH  - Dermatitis, Allergic Contact/*etiology/prevention & control
MH  - Dose-Response Relationship, Drug
MH  - Humans
MH  - Local Lymph Node Assay
MH  - Nitriles/*toxicity
MH  - Preservatives, Pharmaceutical/*toxicity
MH  - Reproducibility of Results
MH  - Risk Assessment
MH  - Skin/*drug effects
MH  - Skin Tests
RF  - 39
EDAT- 2009/11/04 06:00
MHDA- 2010/05/07 06:00
CRDT- 2009/11/04 06:00
PHST- 2009/11/04 06:00 [entrez]
PHST- 2009/11/04 06:00 [pubmed]
PHST- 2010/05/07 06:00 [medline]
AID - 10.3109/15569520903351151 [doi]
PST - ppublish
SO  - Cutan Ocul Toxicol. 2010 Mar;29(1):4-9. doi: 10.3109/15569520903351151.