PMID- 19885011
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20220309
IS  - 2093-3827 (Electronic)
IS  - 1226-4512 (Print)
IS  - 1226-4512 (Linking)
VI  - 13
IP  - 4
DP  - 2009 Aug
TI  - Naringin Protects against Rotenone-induced Apoptosis in Human Neuroblastoma 
      SH-SY5Y Cells.
PG  - 281-5
LID - 10.4196/kjpp.2009.13.4.281 [doi]
AB  - Rotenone, a mitochondrial complex I inhibitor, can induce the pathological 
      features of Parkinson's disease (PD). In the present study, naringin, a 
      grapefruit flavonoid, inhibited rotenone-induced cell death in human 
      neuroblastoma SH-SY5Y cells. We assessed cell death and apoptosis by measuring 
      mitogen-activated protein kinase (MAPKs) and caspase (CASPs) activities and by 
      performing 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) 
      assay, 4,6-diamidino-2-phenylindole (DAPI) staining, and terminal 
      deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) staining. 
      Naringin also blocked rotenone-induced phosphorylation of Jun NH2-terminal 
      protein kinase (JNK) and P38, and prevented changes in B-cell CLL/lymphoma 2 
      (BCL2) and BCL2-associated X protein (BAX) expression levels. In addition, 
      naringin reduced the enzyme activity of caspase 3 and cleavages of caspase 9, 
      poly (ADP-ribose) polymerase (PARP), and caspase 3. These results suggest that 
      naringin has a neuroprotective effect on rotenone-induced cell death in human 
      neuroblastoma SH-SY5Y cells.
FAU - Kim, Hak-Jae
AU  - Kim HJ
AD  - Department of Pharmacology and Kohwang Medical Research Institute, School of 
      Medicine, Kyung Hee University, Seoul 130-701, Korea.
FAU - Song, Jeong Yoon
AU  - Song JY
FAU - Park, Hae Jeong
AU  - Park HJ
FAU - Park, Hyun-Kyung
AU  - Park HK
FAU - Yun, Dong Hwan
AU  - Yun DH
FAU - Chung, Joo-Ho
AU  - Chung JH
LA  - eng
PT  - Journal Article
DEP - 20090831
PL  - Korea (South)
TA  - Korean J Physiol Pharmacol
JT  - The Korean journal of physiology & pharmacology : official journal of the Korean 
      Physiological Society and the Korean Society of Pharmacology
JID - 9709505
PMC - PMC2766708
OTO - NOTNLM
OT  - Apoptosis
OT  - Naringin
OT  - Parkinson's disease
OT  - Rotenone
OT  - SH-SY5Y
EDAT- 2009/11/04 06:00
MHDA- 2009/11/04 06:01
PMCR- 2009/08/01
CRDT- 2009/11/04 06:00
PHST- 2009/05/25 00:00 [received]
PHST- 2009/06/19 00:00 [revised]
PHST- 2009/07/20 00:00 [accepted]
PHST- 2009/11/04 06:00 [entrez]
PHST- 2009/11/04 06:00 [pubmed]
PHST- 2009/11/04 06:01 [medline]
PHST- 2009/08/01 00:00 [pmc-release]
AID - 10.4196/kjpp.2009.13.4.281 [doi]
PST - ppublish
SO  - Korean J Physiol Pharmacol. 2009 Aug;13(4):281-5. doi: 
      10.4196/kjpp.2009.13.4.281. Epub 2009 Aug 31.