PMID- 19886899
OWN - NLM
STAT- MEDLINE
DCOM- 20110617
LR  - 20110414
IS  - 1469-0691 (Electronic)
IS  - 1198-743X (Linking)
VI  - 16
IP  - 9
DP  - 2010 Sep
TI  - Mannose-binding lectin in pre-menopausal women with recurrent urinary tract 
      infections.
PG  - 1394-8
LID - 10.1111/j.1469-0691.2009.03107.x [doi]
AB  - Mannose-binding lectin (MBL) comprises an oligomeric serum protein that is a 
      member of the collectin class of the C-type lectin superfamily. Its deficiency is 
      genetically determined and confers predisposition to recurrent infections as well 
      as increased infection severity. This correlation has been demonstrated in 
      recurrent furunculosis caused by Staphylococcus aureus, and in pneumococcal and 
      Candida infections. The present study aimed to determine whether there is a 
      correlation between MBL serum levels and recurrent urinary tact infections (UTI) 
      in pre-menopausal women. The present aged-matched double-blind controlled study 
      was conducted in 100 pre-menopausal adult women: 50 who suffered from recurrent 
      UTI and 50 without UTI. The MBL concentration was measured in a single serum 
      sample from each patient using an enzyme-linked immunosorbent assay. MBL serum 
      levels [median (range)] were 2500 (4-12,000) ng/mL and 2105 (4-22,800) ng/mL for 
      the research and control groups, respectively. The results from the two groups 
      were compared and were not statistically different (p 0.4). According to these 
      results, MBL serum levels are not associated with an increased risk for recurrent 
      UTI in pre-menopausal women.
CI  - (c) 2010 The Authors. Journal Compilation (c) 2010 European Society of Clinical 
      Microbiology and Infectious Diseases.
FAU - Colodner, R
AU  - Colodner R
AD  - Laboratory Medicine Department, Ha'Emek Medical Center, Afula, Israel. 
      colodner_ra@clalit.org.il
FAU - Nitzan, O
AU  - Nitzan O
FAU - Chazan, B
AU  - Chazan B
FAU - Edelstein, H
AU  - Edelstein H
FAU - Raz, R
AU  - Raz R
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Microbiol Infect
JT  - Clinical microbiology and infection : the official publication of the European 
      Society of Clinical Microbiology and Infectious Diseases
JID - 9516420
RN  - 0 (Mannose-Binding Lectin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Case-Control Studies
MH  - Double-Blind Method
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Mannose-Binding Lectin/*blood/deficiency
MH  - Middle Aged
MH  - *Premenopause
MH  - Recurrence
MH  - Urinary Tract Infections/*epidemiology
MH  - Young Adult
EDAT- 2009/11/06 06:00
MHDA- 2011/06/18 06:00
CRDT- 2009/11/06 06:00
PHST- 2009/11/06 06:00 [entrez]
PHST- 2009/11/06 06:00 [pubmed]
PHST- 2011/06/18 06:00 [medline]
AID - S1198-743X(14)60682-0 [pii]
AID - 10.1111/j.1469-0691.2009.03107.x [doi]
PST - ppublish
SO  - Clin Microbiol Infect. 2010 Sep;16(9):1394-8. doi: 
      10.1111/j.1469-0691.2009.03107.x.