PMID- 19887773
OWN - NLM
STAT- MEDLINE
DCOM- 20100610
LR  - 20211020
IS  - 1423-0194 (Electronic)
IS  - 0028-3835 (Print)
IS  - 0028-3835 (Linking)
VI  - 91
IP  - 2
DP  - 2010
TI  - Estrogen-induced sexual incentive motivation, proceptivity and receptivity depend 
      on a functional estrogen receptor alpha in the ventromedial nucleus of the 
      hypothalamus but not in the amygdala.
PG  - 142-54
LID - 10.1159/000255766 [doi]
AB  - The display of copulatory behaviors usually requires the presence of a mate and 
      is, therefore, preceded by a search for and approach to a potential partner. The 
      intensity of approach behaviors is determined by a process labeled sexual 
      incentive motivation. Although it is known that female sexual motivation depends 
      on estrogens, their site of action within the brain is unknown. In the present 
      experiment, we obtained data relevant to this issue. An shRNA encoded within an 
      adeno-associated viral (AAV) vector directed against the estrogen receptor alpha 
      (ERalpha) gene (or containing a nonsense base sequence as a control treatment) 
      was injected bilaterally into the ventromedial nucleus of the hypothalamus (VMN) 
      or the posterodorsal amygdala (MePDA) of female rats. After an 80% reduction of 
      the number of ERalpha in the VMN, sexual incentive motivation was absent after 
      treatment with estradiol and progesterone. Proceptivity and receptivity were also 
      much reduced, while the number of rejections was enhanced. Suppression of the 
      ERalpha in the MePDA lacked these effects. Likewise, the inactive control AAV 
      vector failed to modify any behavior. Thus, the ERalpha in the VMN, but not in 
      the MePDA, is important for proceptivity and receptivity as well as for sexual 
      incentive motivation. These results show that ERalpha in the VMN is crucial for 
      the entire sequence of behavioral events from the processes leading to the 
      establishment of sexual contact until the accomplishment of copulatory behaviors.
CI  - Copyright 2009 S. Karger AG, Basel.
FAU - Spiteri, Thierry
AU  - Spiteri T
AD  - Department of Psychology, University of Tromso, Tromso, Norway.
FAU - Musatov, Sergei
AU  - Musatov S
FAU - Ogawa, Sonoko
AU  - Ogawa S
FAU - Ribeiro, Ana
AU  - Ribeiro A
FAU - Pfaff, Donald W
AU  - Pfaff DW
FAU - Agmo, Anders
AU  - Agmo A
LA  - eng
GR  - HD 05751/HD/NICHD NIH HHS/United States
GR  - R37 HD005751/HD/NICHD NIH HHS/United States
GR  - R01 HD005751/HD/NICHD NIH HHS/United States
GR  - MH 38273/MH/NIMH NIH HHS/United States
GR  - R01 MH038273/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20091104
PL  - Switzerland
TA  - Neuroendocrinology
JT  - Neuroendocrinology
JID - 0035665
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (RNA, Small Interfering)
RN  - 4G7DS2Q64Y (Progesterone)
RN  - 4TI98Z838E (Estradiol)
SB  - IM
MH  - Amygdala/*physiology
MH  - Animals
MH  - Copulation/*physiology
MH  - Estradiol/*pharmacology
MH  - Estrogen Receptor alpha/*genetics/metabolism
MH  - Female
MH  - Gene Knockdown Techniques
MH  - Male
MH  - Ovariectomy
MH  - Posture
MH  - Progesterone/pharmacology
MH  - RNA, Small Interfering/pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Sexual Behavior, Animal/*physiology
MH  - Ventromedial Hypothalamic Nucleus/*physiology
PMC - PMC2918652
EDAT- 2009/11/06 06:00
MHDA- 2010/06/11 06:00
PMCR- 2011/03/01
CRDT- 2009/11/06 06:00
PHST- 2008/10/21 00:00 [received]
PHST- 2009/05/23 00:00 [accepted]
PHST- 2009/11/06 06:00 [entrez]
PHST- 2009/11/06 06:00 [pubmed]
PHST- 2010/06/11 06:00 [medline]
PHST- 2011/03/01 00:00 [pmc-release]
AID - 000255766 [pii]
AID - nen0091-0142 [pii]
AID - 10.1159/000255766 [doi]
PST - ppublish
SO  - Neuroendocrinology. 2010;91(2):142-54. doi: 10.1159/000255766. Epub 2009 Nov 4.