PMID- 19887823
OWN - NLM
STAT- MEDLINE
DCOM- 20100205
LR  - 20140730
IS  - 1423-0143 (Electronic)
IS  - 1420-4096 (Linking)
VI  - 32
IP  - 5
DP  - 2009
TI  - Associations of adiponectin with paraoxonase 1 and sE-selectin in hemodialyzed 
      patients.
PG  - 360-5
LID - 10.1159/000254335 [doi]
AB  - BACKGROUND/AIMS: In hemodialyzed (HD) patients, adiponectin and sE-selectin 
      levels are elevated, while antioxidant paraoxonase 1 activity (PON1) is 
      decreased. We determined if the hyperadiponectinemia in HD patients has a 
      protective effect on the decrease in PON1 and elevation in sE-selectin in kidney 
      failure. METHODS AND DESIGN: Predialysis serum adiponectin, PON1 and sE-selectin 
      as well as other metabolic variables were measured in 70 HD patients. RESULTS: 
      Adiponectin had (1) no association with PON1 or sE-selectin, (2) a positive 
      association with dialysis efficiency and HDL-C, and (3) an inverse association 
      with BMI, waist circumference, HOMA IR, triglyceride, hsCRP, fibrinogen, and 
      albumin. Moreover, albumin, BMI, and HOMA-IR were independent negative predictors 
      of adiponectin. CONCLUSIONS: In kidney failure, in contrast to normal renal 
      function, higher adiponectin levels had no correlation with PON1 activity or the 
      sE-selectin level. However, adiponectin has an association with dialysis 
      efficiency and, similar to individuals with preserved kidney function, traits of 
      metabolic syndrome. In addition to BMI and HOMA-IR, the serum albumin 
      concentration is also one of the independent negative predictors of the serum 
      adiponectin level. Collectively, these findings may add details to the 
      understanding of the role that adiponectin plays in chronic renal disease related 
      to 'reverse epidemiology'.
CI  - Copyright 2009 S. Karger AG, Basel.
FAU - Peti, Attila
AU  - Peti A
AD  - Institute of Laboratory Medicine, University of Pecs, Pecs, Hungary.
FAU - Csiky, Botond
AU  - Csiky B
FAU - Guth, Eszter
AU  - Guth E
FAU - Kenyeres, Peter
AU  - Kenyeres P
FAU - Varga, Zsuzsa
AU  - Varga Z
FAU - Seres, Ildiko
AU  - Seres I
FAU - Jeney, Zoltan
AU  - Jeney Z
FAU - Juhasz, Maria
AU  - Juhasz M
FAU - Mezosi, Emese
AU  - Mezosi E
FAU - Paragh, Gyorgy
AU  - Paragh G
FAU - Kovacs, Gabor L
AU  - Kovacs GL
FAU - Bajnok, Laszlo
AU  - Bajnok L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091103
PL  - Switzerland
TA  - Kidney Blood Press Res
JT  - Kidney & blood pressure research
JID - 9610505
RN  - 0 (Adiponectin)
RN  - 0 (E-Selectin)
RN  - 0 (Triglycerides)
RN  - 9001-32-5 (Fibrinogen)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 3.1.8.1 (Aryldialkylphosphatase)
SB  - IM
MH  - Adiponectin/*blood
MH  - Aged
MH  - Aryldialkylphosphatase/*blood
MH  - Body Mass Index
MH  - C-Reactive Protein/metabolism
MH  - Cross-Sectional Studies
MH  - E-Selectin/*blood
MH  - Female
MH  - Fibrinogen/metabolism
MH  - Humans
MH  - Kidney Diseases/*blood/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Regression Analysis
MH  - *Renal Dialysis
MH  - Renal Insufficiency/*blood/*therapy
MH  - Triglycerides/blood
EDAT- 2009/11/06 06:00
MHDA- 2010/02/06 06:00
CRDT- 2009/11/06 06:00
PHST- 2009/04/21 00:00 [received]
PHST- 2009/09/01 00:00 [accepted]
PHST- 2009/11/06 06:00 [entrez]
PHST- 2009/11/06 06:00 [pubmed]
PHST- 2010/02/06 06:00 [medline]
AID - 000254335 [pii]
AID - 10.1159/000254335 [doi]
PST - ppublish
SO  - Kidney Blood Press Res. 2009;32(5):360-5. doi: 10.1159/000254335. Epub 2009 Nov 
      3.