PMID- 19887908
OWN - NLM
STAT- MEDLINE
DCOM- 20100203
LR  - 20200930
IS  - 1551-4005 (Electronic)
IS  - 1551-4005 (Linking)
VI  - 8
IP  - 23
DP  - 2009 Dec
TI  - The dendritic cell life cycle.
PG  - 3816-21
AB  - Dendritic cells (DCs) are a special class of leukocytes actively involved in 
      initiating innate and adaptive immune responses against invading pathogens. They 
      play a fundamental role in determining both the type and efficiency of adaptive 
      immune reactions. In particular, the efficiency of adaptive responses is strictly 
      correlated with the survival of the DCs that have encountered the antigen. In 
      physiological conditions, the rapid death of DCs by apoptosis after an encounter 
      with a microbe is important to prevent both aberrant activation and autoimmunity. 
      The mechanism leading to DC apoptosis after exposure to lipopolysaccharide (LPS) 
      was recently elucidated, with activation of the c2 and c3 isoforms of nuclear 
      factor of activated T cells (NFAT) playing a particularly important role in this 
      process. In particular, the exposure of DCs to LPS induces the activation of 
      Src-family kinases and phospholipase C (PLC)gamma2, the influx of extracellular 
      Ca(2+) and calcineurin-dependent nuclear NFAT translocation. The initiation of 
      this pathway is independent of TLR4 engagement and depends exclusively on CD14. 
      We also consider here the possible role of CD14 in initiating this pathway and 
      the way in which the c2 and c3 isoforms of NFAT exert their pro-apoptotic 
      effects.
FAU - Granucci, Francesca
AU  - Granucci F
AD  - Department of Biotechnology and Bioscience, University of Milano-Bicocca, Milan, 
      Italy. francesca.granucci@unimib.it
FAU - Zanoni, Ivan
AU  - Zanoni I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20091204
PL  - United States
TA  - Cell Cycle
JT  - Cell cycle (Georgetown, Tex.)
JID - 101137841
RN  - 0 (Lipopolysaccharide Receptors)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (NFATC Transcription Factors)
RN  - 0 (Toll-Like Receptor 4)
RN  - EC 2.7.10.2 (src-Family Kinases)
RN  - EC 3.1.3.16 (Calcineurin)
RN  - EC 3.1.4.3 (Phospholipase C gamma)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Apoptosis
MH  - Calcineurin/metabolism
MH  - Calcium/metabolism
MH  - Dendritic Cells/cytology/*immunology
MH  - Lipopolysaccharide Receptors/metabolism
MH  - Lipopolysaccharides/pharmacology
MH  - NFATC Transcription Factors/metabolism/physiology
MH  - Phospholipase C gamma/metabolism
MH  - Toll-Like Receptor 4/metabolism
MH  - src-Family Kinases/metabolism
RF  - 58
EDAT- 2009/11/06 06:00
MHDA- 2010/02/04 06:00
CRDT- 2009/11/06 06:00
PHST- 2009/11/06 06:00 [entrez]
PHST- 2009/11/06 06:00 [pubmed]
PHST- 2010/02/04 06:00 [medline]
AID - 9998 [pii]
AID - 10.4161/cc.8.23.9998 [doi]
PST - ppublish
SO  - Cell Cycle. 2009 Dec;8(23):3816-21. doi: 10.4161/cc.8.23.9998. Epub 2009 Dec 4.