PMID- 19888649
OWN - NLM
STAT- MEDLINE
DCOM- 20110315
LR  - 20220716
IS  - 1573-7217 (Electronic)
IS  - 0167-6806 (Print)
IS  - 0167-6806 (Linking)
VI  - 121
IP  - 3
DP  - 2010 Jun
TI  - Serum insulin-like growth factor (IGF)-1 and IGF binding protein-3 in relation to 
      breast cancer among Hispanic and white, non-Hispanic women in the US Southwest.
PG  - 661-9
LID - 10.1007/s10549-009-0609-5 [doi]
AB  - Insulin-like growth factor 1 (IGF-1) and IGF binding protein 3 (IGFBP-3) have 
      been positively associated with breast cancer, especially among premenopausal 
      women. Hispanic women have lower levels of IGF-1 and IGFBP-3 than non-Hispanic 
      white (NHW) women, although no studies have adequately assessed the relationship 
      among IGF-1, IGFBP-3, and breast cancer in Hispanic women. We investigated the 
      association among IGF-1, IGFBP-3, and breast cancer within a subset of 
      participants (n = 184 cases, 522 controls) of a population-based case-control 
      study of women living in the U.S. Southwest. Serum levels of IGF-1 and IGFBP-3 
      were measured in fasting blood samples, and associations among IGF-1, IGFBP-3, 
      and breast cancer were calculated using logistic regression, adjusting for age, 
      study center, ethnicity, education, recent hormone exposure, body mass index, 
      parity, total energy expenditure, total calories, and cholesterol. Both IGF-1 and 
      IGFBP-3 were statistically significantly associated with breast cancer overall 
      (highest vs. lowest quartile (Q4 vs. Q1) for IGF-1: odds ratio (OR) = 1.92, 95% 
      confidence interval (CI) = 1.07-3.43); for IGFBP-3: OR = 3.04, 95% CI = 
      1.63-5.67). Positive associations were observed for both premenopausal breast 
      cancer and postmenopausal breast cancer. IGF-1 was associated with breast cancer 
      in NHW women (Q4 vs. Q1: OR = 2.82, 95% CI = 1.36-5.83), but not in Hispanic 
      women (Q4 vs. Q1: OR = 0.81, 95% CI = 0.29-2.27). IGFBP-3 was associated with 
      breast cancer in both ethnic groups (Q4 vs. Q1 for NHW: OR = 3.32, 95% CI = 
      1.45-7.60; Q4 vs. Q1 for Hispanics: OR = 2.15, 95% CI = 0.76-6.04). In 
      conclusion, the association between IGF-1 and breast cancer differed by 
      ethnicity, while no ethnic differences were observed in IGFBP-3-associated breast 
      cancer.
FAU - Rollison, Dana E
AU  - Rollison DE
AD  - Division of Cancer Prevention and Control, H. Lee Moffitt Cancer Center and 
      Research Institute, Magnolia Drive, Tampa, FL 33612, USA. 
      dana.rollison@moffitt.org
FAU - Giuliano, Anna R
AU  - Giuliano AR
FAU - Risendal, Betsy C
AU  - Risendal BC
FAU - Sweeney, Carol
AU  - Sweeney C
FAU - Boulware, David
AU  - Boulware D
FAU - Laronga, Christine
AU  - Laronga C
FAU - Baumgartner, Kathy B
AU  - Baumgartner KB
FAU - Byers, Tim
AU  - Byers T
FAU - Slattery, Martha L
AU  - Slattery ML
LA  - eng
GR  - CA078682/CA/NCI NIH HHS/United States
GR  - R01 CA078552/CA/NCI NIH HHS/United States
GR  - R01 CA078762/CA/NCI NIH HHS/United States
GR  - CA078552/CA/NCI NIH HHS/United States
GR  - #N01-PC-67000/PC/NCI NIH HHS/United States
GR  - CA078762/CA/NCI NIH HHS/United States
GR  - CA078802/CA/NCI NIH HHS/United States
GR  - R01 CA078802/CA/NCI NIH HHS/United States
GR  - R01 CA078682/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20091104
PL  - Netherlands
TA  - Breast Cancer Res Treat
JT  - Breast cancer research and treatment
JID - 8111104
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/*blood
MH  - Breast Neoplasms/*ethnology
MH  - Case-Control Studies
MH  - Female
MH  - *Hispanic or Latino/statistics & numerical data
MH  - Humans
MH  - Insulin-Like Growth Factor Binding Protein 3/*blood
MH  - Insulin-Like Growth Factor I/*metabolism
MH  - Logistic Models
MH  - Middle Aged
MH  - Postmenopause
MH  - Premenopause
MH  - Southwestern United States/epidemiology
PMC - PMC9278514
MID - NIHMS1063509
EDAT- 2009/11/06 06:00
MHDA- 2011/03/16 06:00
PMCR- 2022/07/13
CRDT- 2009/11/06 06:00
PHST- 2009/08/11 00:00 [received]
PHST- 2009/10/15 00:00 [accepted]
PHST- 2009/11/06 06:00 [entrez]
PHST- 2009/11/06 06:00 [pubmed]
PHST- 2011/03/16 06:00 [medline]
PHST- 2022/07/13 00:00 [pmc-release]
AID - 10.1007/s10549-009-0609-5 [doi]
PST - ppublish
SO  - Breast Cancer Res Treat. 2010 Jun;121(3):661-9. doi: 10.1007/s10549-009-0609-5. 
      Epub 2009 Nov 4.