PMID- 19889757
OWN - NLM
STAT- MEDLINE
DCOM- 20100112
LR  - 20211020
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Print)
IS  - 0022-538X (Linking)
VI  - 84
IP  - 2
DP  - 2010 Jan
TI  - Investigation of clade B New World arenavirus tropism by using chimeric GP1 
      proteins.
PG  - 1176-82
LID - 10.1128/JVI.01625-09 [doi]
AB  - Clade B of the New World arenaviruses contains both pathogenic and nonpathogenic 
      members, whose surface glycoproteins (GPs) are characterized by different 
      abilities to use the human transferrin receptor type 1 (hTfR1) protein as a 
      receptor. Using closely related pairs of pathogenic and nonpathogenic viruses, we 
      investigated the determinants of the GP1 subunit that confer these different 
      characteristics. We identified a central region (residues 85 to 221) in the 
      Guanarito virus GP1 that was sufficient to interact with hTfR1, with residues 159 
      to 221 being essential. The recently solved structure of part of the Machupo 
      virus GP1 suggests an explanation for these requirements.
FAU - Martin, Vanessa K
AU  - Martin VK
AD  - USC Keck School of Medicine, 2011 Zonal Avenue, HMR502, Los Angeles, CA 90033, 
      USA.
FAU - Droniou-Bonzom, Magali E
AU  - Droniou-Bonzom ME
FAU - Reignier, Therese
AU  - Reignier T
FAU - Oldenburg, Jill E
AU  - Oldenburg JE
FAU - Cox, Alex U
AU  - Cox AU
FAU - Cannon, Paula M
AU  - Cannon PM
LA  - eng
GR  - U54 AI065359/AI/NIAID NIH HHS/United States
GR  - 1U54 AI065359/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20091104
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (Glycoproteins)
RN  - 0 (Receptors, Transferrin)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 0 (Viral Envelope Proteins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Arenaviruses, New World/classification/genetics/*pathogenicity/*physiology
MH  - CHO Cells
MH  - Cell Line
MH  - Cricetinae
MH  - Cricetulus
MH  - Glycoproteins/chemistry/genetics/metabolism
MH  - Humans
MH  - Models, Molecular
MH  - Molecular Sequence Data
MH  - Receptors, Transferrin/metabolism
MH  - *Recombinant Fusion Proteins/chemistry/genetics/metabolism
MH  - *Viral Envelope Proteins/chemistry/genetics/metabolism
PMC - PMC2798354
EDAT- 2009/11/06 06:00
MHDA- 2010/01/13 06:00
PMCR- 2010/07/01
CRDT- 2009/11/06 06:00
PHST- 2009/11/06 06:00 [entrez]
PHST- 2009/11/06 06:00 [pubmed]
PHST- 2010/01/13 06:00 [medline]
PHST- 2010/07/01 00:00 [pmc-release]
AID - JVI.01625-09 [pii]
AID - 1625-09 [pii]
AID - 10.1128/JVI.01625-09 [doi]
PST - ppublish
SO  - J Virol. 2010 Jan;84(2):1176-82. doi: 10.1128/JVI.01625-09. Epub 2009 Nov 4.