PMID- 19890014
OWN - NLM
STAT- MEDLINE
DCOM- 20091117
LR  - 20211020
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 29
IP  - 44
DP  - 2009 Nov 4
TI  - Sleep deprivation differentially impairs cognitive performance in abstinent 
      methylenedioxymethamphetamine ("Ecstasy") users.
PG  - 14050-6
LID - 10.1523/JNEUROSCI.4654-09.2009 [doi]
AB  - Methylenedioxymethamphetamine (MDMA; "Ecstasy") is a popular recreational drug 
      and brain serotonin (5-HT) neurotoxin. Neuroimaging data indicate that some human 
      MDMA users develop persistent deficits in brain 5-HT neuronal markers. Although 
      the consequences of MDMA-induced 5-HT neurotoxicity are not fully understood, 
      abstinent MDMA users have been found to have subtle cognitive deficits and 
      altered sleep architecture. The present study sought to test the hypothesis that 
      sleep disturbance plays a role in cognitive deficits in MDMA users. Nineteen 
      abstinent MDMA users and 21 control subjects participated in a 5 d inpatient 
      study in a clinical research unit. Baseline sleep quality was measured using the 
      Pittsburgh Sleep Quality Inventory. Cognitive performance was tested three times 
      daily using a computerized cognitive battery. On the third day of admission, 
      subjects began a 40 h sleep deprivation period and continued cognitive testing 
      using the same daily schedule. At baseline, MDMA users performed less accurately 
      than controls on a task of working memory and more impulsively on four of the 
      seven computerized tests. During sleep deprivation, MDMA users, but not controls, 
      became increasingly impulsive, performing more rapidly at the expense of accuracy 
      on tasks of working and short-term memory. Tests of mediation implicated baseline 
      sleep disturbance in the cognitive decline seen during sleep deprivation. These 
      findings are the first to demonstrate that memory problems in MDMA users may be 
      related, at least in part, to sleep disturbance and suggest that cognitive 
      deficits in MDMA users may become more prominent in situations associated with 
      sleep deprivation.
FAU - McCann, Una D
AU  - McCann UD
AD  - Department of Psychiatry and Neurology, The Johns Hopkins School of Medicine, 
      Baltimore, MD 21224, USA. umccann@jhmi.edu
FAU - Wilson, Michael J
AU  - Wilson MJ
FAU - Sgambati, Francis P
AU  - Sgambati FP
FAU - Ricaurte, George A
AU  - Ricaurte GA
LA  - eng
GR  - R01 DA010217-08/DA/NIDA NIH HHS/United States
GR  - DA01796401/DA/NIDA NIH HHS/United States
GR  - M01 RR002719/RR/NCRR NIH HHS/United States
GR  - R01 DA005938/DA/NIDA NIH HHS/United States
GR  - R01 DA016563/DA/NIDA NIH HHS/United States
GR  - R01 DA016563-04/DA/NIDA NIH HHS/United States
GR  - R01 DA025686/DA/NIDA NIH HHS/United States
GR  - DA05938/DA/NIDA NIH HHS/United States
GR  - R01 DA010217/DA/NIDA NIH HHS/United States
GR  - DA16563/DA/NIDA NIH HHS/United States
GR  - R01 DA025686-02/DA/NIDA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adult
MH  - Cognition/physiology
MH  - Cognition Disorders/etiology/*physiopathology
MH  - Female
MH  - Humans
MH  - Male
MH  - *N-Methyl-3,4-methylenedioxyamphetamine/administration & dosage
MH  - Psychomotor Performance/*physiology
MH  - Sleep Deprivation/complications/*physiopathology
MH  - Substance-Related Disorders/complications/*physiopathology
MH  - Young Adult
PMC - PMC3047479
MID - NIHMS274201
EDAT- 2009/11/06 06:00
MHDA- 2009/11/18 06:00
PMCR- 2010/05/04
CRDT- 2009/11/06 06:00
PHST- 2009/11/06 06:00 [entrez]
PHST- 2009/11/06 06:00 [pubmed]
PHST- 2009/11/18 06:00 [medline]
PHST- 2010/05/04 00:00 [pmc-release]
AID - 29/44/14050 [pii]
AID - 3543625 [pii]
AID - 10.1523/JNEUROSCI.4654-09.2009 [doi]
PST - ppublish
SO  - J Neurosci. 2009 Nov 4;29(44):14050-6. doi: 10.1523/JNEUROSCI.4654-09.2009.