PMID- 19891658
OWN - NLM
STAT- MEDLINE
DCOM- 20100903
LR  - 20100604
IS  - 1600-0560 (Electronic)
IS  - 0303-6987 (Linking)
VI  - 37
IP  - 6
DP  - 2010 Jun
TI  - The phenotypic profile of dermatomyositis and lupus erythematosus: a comparative 
      analysis.
PG  - 659-71
LID - 10.1111/j.1600-0560.2009.01443.x [doi]
AB  - BACKGROUND: The mechanisms which regulate cutaneous inflammation in the setting 
      of collagen vascular disease have been a topic of recent interest; emphasis has 
      been placed on type I interferon-associated recruitment of CXCR3+ lymphocytes in 
      dermatomyositis (DM). METHODS: On a total of 42 biopsies from patients with DM, 
      systemic lupus erythematosus (SLE), discoid lupus erythematosus (DLE) and 
      subacute cutaneous lupus erythematosus (SCLE) comprehensive phenotypic studies 
      were performed to explore the practical value of phenotypic analysis in the 
      subclassification of lesions of collagen vascular disease. RESULTS: The 
      infiltrate in DM was of mild intensity compared to lupus erythematosus (LE). The 
      dominant mononuclear cell in DM exhibited a CD4/CXCR3-positive phenotype while 
      biopsies of SLE typically showed a dearth of CXCR3-positive cells. CD8 and CD20 
      lymphocytes were greatest in SLE and DLE, respectively. CD123 plasmacytoid 
      dendritic cells, seen in most cases, were most frequent in cases of SCLE; CD83 
      expression was minimal. Endothelial MXA expression was a characteristic feature 
      of DM. CD123 and MXA expression within inflammatory cells and keratinocytes was 
      most conspicuous in areas of interface injury. Cutaneous lymphocyte antigen (CLA) 
      expression was diminished in the dermal infiltrate in most cases of DM and LE. T 
      regulatory cells never exceeded 15% of the infiltrate and were the least in the 
      setting of DM and LE. CONCLUSIONS: An interferon-alpha-inducible cytokine milieu 
      is common in SLE, DLE, SCLE and DM. In addition, there are phenotypic differences 
      as alluded to above that may be of some practical value in separating these 
      distinctive subsets. Features not previously emphasized such as MXA endothelial 
      cell staining in DM and the lack of staining for CD83 and CLA in lesions of 
      collagen vascular disease may be of diagnostic value.
FAU - Magro, Cynthia M
AU  - Magro CM
AD  - Department of Pathology, New York Presbyterian Hospital-Weill Cornell Medical 
      Center, New York, NY 10044, USA. cym2003@med.cornell.edu
FAU - Segal, Jeremy P
AU  - Segal JP
FAU - Crowson, A Neil
AU  - Crowson AN
FAU - Chadwick, Paul
AU  - Chadwick P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20091104
PL  - United States
TA  - J Cutan Pathol
JT  - Journal of cutaneous pathology
JID - 0425124
RN  - 0 (Antigens, CD)
SB  - IM
MH  - Antigens, CD/*metabolism
MH  - Dermatomyositis/*metabolism/pathology
MH  - Humans
MH  - Lupus Erythematosus, Cutaneous/*metabolism/pathology
MH  - Lupus Erythematosus, Systemic/*metabolism/pathology
MH  - Retrospective Studies
MH  - Skin/*metabolism/pathology
EDAT- 2009/11/07 06:00
MHDA- 2010/09/04 06:00
CRDT- 2009/11/07 06:00
PHST- 2009/11/07 06:00 [entrez]
PHST- 2009/11/07 06:00 [pubmed]
PHST- 2010/09/04 06:00 [medline]
AID - CUP1443 [pii]
AID - 10.1111/j.1600-0560.2009.01443.x [doi]
PST - ppublish
SO  - J Cutan Pathol. 2010 Jun;37(6):659-71. doi: 10.1111/j.1600-0560.2009.01443.x. 
      Epub 2009 Nov 4.