PMID- 19891989
OWN - NLM
STAT- MEDLINE
DCOM- 20100413
LR  - 20211020
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Print)
IS  - 0166-4328 (Linking)
VI  - 207
IP  - 2
DP  - 2010 Mar 5
TI  - Behavioral, thermal and neurochemical effects of acute and chronic 
      3,4-methylenedioxymethamphetamine ("Ecstasy") self-administration.
PG  - 500-7
LID - 10.1016/j.bbr.2009.10.038 [doi]
AB  - 3,4-Methylenedioxymethamphetamine (MDMA) is a popular methamphetamine derivative 
      associated with young adults and all-night dance parties. However, the enduring 
      effects of MDMA at voluntary intake levels have not been extensively 
      investigated. In this study, MDMA-influenced behaviors and core temperatures were 
      assessed over the course of 20 daily MDMA self-administration sessions in rats. 
      In vivo microdialysis techniques were used in a subsequent MDMA challenge test 
      session to determine extracellular nucleus accumbens dopamine (NAcc DA) and 
      serotonin (5-HT) levels in MDMA-experienced and naive animals before and after a 
      self-administered MDMA injection (3.0mg/kg, i.v.). During self-administration 
      sessions, gradual and significant increases in MDMA intake and MDMA-stimulated 
      locomotor activity were observed across sessions. Core temperature significantly 
      decreased during initial MDMA sessions, but was unaltered by the last 10 
      sessions. In the MDMA challenge test, MDMA-naive rats showed significantly higher 
      NAcc 5-HT responses compared to MDMA-experienced rats, though MDMA experience did 
      not affect the magnitude of NAcc DA response. The overall findings suggest that 
      changes in MDMA-induced responses over the course of increasing levels of drug 
      exposure may reflect the development of tolerance to a number of MDMA effects.
CI  - Published by Elsevier B.V.
FAU - Reveron, Maria Elena
AU  - Reveron ME
AD  - College of Pharmacy, Division of Pharmacology and Toxicology, University of 
      Texas, Austin, TX 78712-0125, USA.
FAU - Maier, Esther Y
AU  - Maier EY
FAU - Duvauchelle, Christine L
AU  - Duvauchelle CL
LA  - eng
GR  - R01 DA014640/DA/NIDA NIH HHS/United States
GR  - R01 DA014640-05/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091103
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Hallucinogens)
RN  - 333DO1RDJY (Serotonin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Body Temperature/*drug effects
MH  - Catheterization
MH  - Conditioning, Operant/drug effects
MH  - Dopamine/metabolism
MH  - Drug Tolerance
MH  - Extracellular Space/drug effects/metabolism
MH  - Hallucinogens/administration & dosage/*pharmacology
MH  - Male
MH  - Microdialysis
MH  - Motor Activity/drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/administration & dosage/*pharmacology
MH  - Nucleus Accumbens/*drug effects/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Self Administration
MH  - Serotonin/metabolism
MH  - Time Factors
PMC - PMC2814985
MID - NIHMS157070
EDAT- 2009/11/07 06:00
MHDA- 2010/04/14 06:00
PMCR- 2011/03/05
CRDT- 2009/11/07 06:00
PHST- 2009/03/20 00:00 [received]
PHST- 2009/10/23 00:00 [revised]
PHST- 2009/10/30 00:00 [accepted]
PHST- 2009/11/07 06:00 [entrez]
PHST- 2009/11/07 06:00 [pubmed]
PHST- 2010/04/14 06:00 [medline]
PHST- 2011/03/05 00:00 [pmc-release]
AID - S0166-4328(09)00661-5 [pii]
AID - 10.1016/j.bbr.2009.10.038 [doi]
PST - ppublish
SO  - Behav Brain Res. 2010 Mar 5;207(2):500-7. doi: 10.1016/j.bbr.2009.10.038. Epub 
      2009 Nov 3.