PMID- 19893256
OWN - NLM
STAT- MEDLINE
DCOM- 20110502
LR  - 20091106
IS  - 1672-7347 (Print)
IS  - 1672-7347 (Linking)
VI  - 34
IP  - 10
DP  - 2009 Oct
TI  - [Expression of MCP-1 in renal tissues of patients with IgA nephropathy].
PG  - 1023-8
AB  - OBJECTIVE: To investigate the differential expression of monocyte chemoattractant 
      protein-1 (MCP-1) in renal biopsy tissues of patients with IgA nephropathy, and 
      to analyse the association between these 2 markers and their effect on various 
      pathologic types of IgA nephropathy. METHODS: According to pathologic type, 88 
      renal biopsy tissues of patients with IgA nephropathy were divided into 4 
      groups:a minimal change group,a mesangial proliferative glomerulonephritis group, 
      a focal sclerosing glomerulonephritis group, and a diffused sclerosing 
      glomerulonephritis group. Immunohistochemical staining was used to detect the in 
      situ expression of MCP-1 and CD68 on renal biopsy tissues. The expression levels 
      were semi-quantified by image analysis and clinical data were collected from the 
      patients. RESULTS: The differences in glomerular MCP-1 expressions were not 
      statistically significant among all groups, while the tubulointerstitial MCP-1 
      expressions were statistically different among the 4 groups, with the average 
      scores of 1.43+/-0.60, 5.98+/-0.92, 10.60+/-0.76 and 11.65+/-0.39 for minimal 
      change group, mesangial proliferative glomerulonephritis group, focal sclerotic 
      glomerulonephritis, and diffused sclerotic glomerulonephritis group, 
      respectively. The tubular and interstitial CD68 scores were 0.75+/-0.71, 
      5.87+/-0.96, 10.42+/-0.61, and 11.40+/-0.49 for the 4 groups, with significant 
      differences in both MCP-1 and CD68 among the 4 groups. Correlation analysis 
      indicated a positive correlation between tubulointerstitial MCP-1 and CD68 
      (r=0.688, P<0.01). MCP-1 in tubulointerstitial was significantly correlated with 
      24 h urinary protein excretion(r=0.531, P<0.01). CONCLUSION: MCP-1 plays a 
      critical role in macrophage infiltration in the kidney. MCP-1 is associated with 
      the severity of tubulointerstitial damage and clinical prognosis.
FAU - Sun, Yongchao
AU  - Sun Y
AD  - Department of Nephrology, Third Xiangya Hospital, Central South University, 
      Changsha, China.
FAU - Yuan, Shuguang
AU  - Yuan S
FAU - Xu, Xiangqing
AU  - Xu X
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhong Nan Da Xue Xue Bao Yi Xue Ban
JT  - Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. 
      Medical sciences
JID - 101230586
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Differentiation, Myelomonocytic)
RN  - 0 (CCL2 protein, human)
RN  - 0 (CD68 antigen, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antigens, CD/genetics/metabolism
MH  - Antigens, Differentiation, Myelomonocytic/genetics/metabolism
MH  - Chemokine CCL2/genetics/*metabolism
MH  - Female
MH  - Glomerulonephritis, IGA/*metabolism/pathology
MH  - Humans
MH  - Kidney Tubules/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Young Adult
EDAT- 2009/11/07 06:00
MHDA- 2011/05/03 06:00
CRDT- 2009/11/07 06:00
PHST- 2009/11/07 06:00 [entrez]
PHST- 2009/11/07 06:00 [pubmed]
PHST- 2011/05/03 06:00 [medline]
AID - 1672-7347(2009)10-1023-06 [pii]
PST - ppublish
SO  - Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2009 Oct;34(10):1023-8.