PMID- 19895570
OWN - NLM
STAT- MEDLINE
DCOM- 20100805
LR  - 20221207
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 75
IP  - 1
DP  - 2010 Jan
TI  - MICA polymorphisms and haplotypes with HLA-B and HLA-DRB1 in Koreans.
PG  - 48-55
LID - 10.1111/j.1399-0039.2009.01396.x [doi]
AB  - Major histocompatibility complex (MHC) class I chain-related gene A (MICA) is 
      located within the human MHC, centromeric to HLA-B and telomeric to HLA-DRB1. The 
      location of MICA in the MHC indicates the presence of linkage disequilibrium with 
      human leukocyte antigen (HLA). Like HLA, MICA is highly polymorphic; however, the 
      information available for MICA polymorphisms is not as comprehensive as that for 
      HLA polymorphisms. We estimated the allelic frequencies of MICA and haplotypes 
      with HLA-B and HLA-DRB1 at high-resolution in a population of 139 unrelated 
      Korean individuals by applying the newly developed method of sequence-based 
      typing (SBT). A total of 17 MICA alleles were identified. The most frequent 
      allele was MICA*010 (19.4%), followed by alleles *00201 (17.6%), *00801 (14.7%), 
      *01201 (9.4%), *004 (8.3%) and *049 (7.9%). The most common two- and three-locus 
      haplotypes were HLA-B*1501-MICA*010 (10.4%), MICA*010-HLA-DRB1*0406 (5.8%) and 
      HLA-B*1501-MICA*010-HLA-DRB1*0406 (5.8%). This is the first study to provide such 
      high-resolution information on the distribution of haplotypes comprising MICA, 
      HLA-B and HLA-DRB1 in Korean individuals, a level of resolution made possible by 
      use of the SBT method. The results of this study should help determine the 
      mechanisms underlying diseases associated with MICA polymorphisms in Korean 
      individuals.
FAU - Sohn, Y-H
AU  - Sohn YH
AD  - Department of Laboratory Medicine, University of Ulsan College of Medicine and 
      Asan Medical Center, Seoul, South Korea.
FAU - Cha, C-H
AU  - Cha CH
FAU - Oh, H-B
AU  - Oh HB
FAU - Kim, M H
AU  - Kim MH
FAU - Choi, S-E
AU  - Choi SE
FAU - Kwon, O-J
AU  - Kwon OJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091106
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (MHC class I-related chain A)
SB  - IM
MH  - Asian People
MH  - Gene Frequency
MH  - HLA-B Antigens/*genetics
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - *Haplotypes
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Major Histocompatibility Complex/genetics
MH  - *Polymorphism, Genetic
EDAT- 2009/11/10 06:00
MHDA- 2010/08/06 06:00
CRDT- 2009/11/10 06:00
PHST- 2009/11/10 06:00 [entrez]
PHST- 2009/11/10 06:00 [pubmed]
PHST- 2010/08/06 06:00 [medline]
AID - TAN1396 [pii]
AID - 10.1111/j.1399-0039.2009.01396.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2010 Jan;75(1):48-55. doi: 10.1111/j.1399-0039.2009.01396.x. 
      Epub 2009 Nov 6.