PMID- 19895590
OWN - NLM
STAT- MEDLINE
DCOM- 20100608
LR  - 20220331
IS  - 1365-2222 (Electronic)
IS  - 0954-7894 (Linking)
VI  - 40
IP  - 2
DP  - 2010 Feb
TI  - The minimal clinically important difference in allergic rhinitis.
PG  - 242-50
LID - 10.1111/j.1365-2222.2009.03381.x [doi]
AB  - BACKGROUND: When presented with results from clinical measurements or research 
      findings, clinicians must first make an interpretation of their importance, not 
      only in statistical terms, but also the 'clinical importance' given the size of 
      the change observed. To do this, they require an understanding of the 
      relationship between their outcome measures, and the patient's perception of 
      change. The minimal clinically important difference (MCID) illustrates this 
      relationship by calculating the smallest change in a given outcome that is 
      meaningful to a patient. There are few reports of calculated MCIDs in the 
      Rhinology literature. OBJECTIVE: To calculate MCIDs for common subjective and 
      objective outcome measures in allergic rhinitis (AR). METHODS: Nine randomized, 
      blinded, placebo-controlled clinical trials in intermittent and persistent AR 
      (pooled subjects, n=204) were analysed using anchor- and distribution-based 
      approaches, applying regression and meta-analysis techniques. RESULTS: MCIDs were 
      obtained for the Mini Rhinoconjunctivitis Quality of Life Questionnaire: 0.4 
      units, peak nasal inspiratory flow: 5 L/min and total nasal symptoms score: 0.55 
      units. Nasal NO measurement changes had no correlation with patient perceptions 
      of benefit. CONCLUSION: Estimates of MCIDs were obtained for common subjective 
      and objective rhinological outcomes. MCIDs can and should be applied by 
      physicians interpreting research findings, as well as researchers reporting their 
      findings. We can then be confident that our changes in practice will be of 
      perceptible benefit to the patient.
FAU - Barnes, M L
AU  - Barnes ML
AD  - Asthma & Allergy Research Group, Department of Medicine and Therapeutics, 
      Ninewells Hospital & Medical School, University of Dundee, Scotland, UK. 
      mr.mlbarnes@gmail.com
FAU - Vaidyanathan, S
AU  - Vaidyanathan S
FAU - Williamson, P A
AU  - Williamson PA
FAU - Lipworth, B J
AU  - Lipworth BJ
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20091105
PL  - England
TA  - Clin Exp Allergy
JT  - Clinical and experimental allergy : journal of the British Society for Allergy 
      and Clinical Immunology
JID - 8906443
RN  - 31C4KY9ESH (Nitric Oxide)
SB  - IM
CIN - Clin Exp Allergy. 2010 Feb;40(2):197-9. PMID: 20015275
MH  - Double-Blind Method
MH  - Humans
MH  - Nitric Oxide/analysis
MH  - Quality of Life
MH  - *Randomized Controlled Trials as Topic
MH  - Regression Analysis
MH  - Rhinitis, Allergic, Perennial/*diagnosis/physiopathology/*psychology
MH  - Sensitivity and Specificity
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
EDAT- 2009/11/10 06:00
MHDA- 2010/06/09 06:00
CRDT- 2009/11/10 06:00
PHST- 2009/11/10 06:00 [entrez]
PHST- 2009/11/10 06:00 [pubmed]
PHST- 2010/06/09 06:00 [medline]
AID - CEA3381 [pii]
AID - 10.1111/j.1365-2222.2009.03381.x [doi]
PST - ppublish
SO  - Clin Exp Allergy. 2010 Feb;40(2):242-50. doi: 10.1111/j.1365-2222.2009.03381.x. 
      Epub 2009 Nov 5.