PMID- 19895714
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20100211
LR  - 20211020
IS  - 1756-994X (Electronic)
IS  - 1756-994X (Linking)
VI  - 1
IP  - 11
DP  - 2009 Nov 6
TI  - Multiple sclerosis: major histocompatibility complexity and antigen presentation.
PG  - 105
LID - 10.1186/gm105 [doi]
AB  - Multiple sclerosis (MS), like many putative autoimmune diseases, has been known 
      to be associated with the human leukocyte antigen (HLA) class II region for more 
      than 3 decades. However, exactly how HLA class II alleles increase the risk of MS 
      is not yet conclusively known. Recent work in large human cohorts has highlighted 
      the fact that nearly all common HLA-DRB1 allelotypes are either positively or 
      negatively associated with the disease, detracting from allele-specific antigen 
      presentation as the sole mechanism of MHC associated disease susceptibility. 
      Here, we put into context recent data on the HLA class II region in MS, including 
      allelic heterogeneity, gene-environment interactions and epigenetics. It is clear 
      that a complete understanding of the epistatic interactions and epigenetic 
      features of this region will be crucial to comprehending disease pathogenesis.
FAU - Ramagopalan, Sreeram V
AU  - Ramagopalan SV
AD  - Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, 
      Headington, Oxford, OX3 7BN, UK.
FAU - Ebers, George C
AU  - Ebers GC
LA  - eng
PT  - Journal Article
DEP - 20091106
PL  - England
TA  - Genome Med
JT  - Genome medicine
JID - 101475844
PMC - PMC2808740
EDAT- 2009/11/10 06:00
MHDA- 2009/11/10 06:01
PMCR- 2010/11/06
CRDT- 2009/11/10 06:00
PHST- 2009/11/10 06:00 [entrez]
PHST- 2009/11/10 06:00 [pubmed]
PHST- 2009/11/10 06:01 [medline]
PHST- 2010/11/06 00:00 [pmc-release]
AID - gm105 [pii]
AID - 10.1186/gm105 [doi]
PST - epublish
SO  - Genome Med. 2009 Nov 6;1(11):105. doi: 10.1186/gm105.